Jung M, Kim JW, Jang JY, Chang YW, Park SH, Kim YH, Kim YW. Recurrent gastric neuroendocrine tumors treated with total gastrectomy. World J Gastroenterol 2015; 21(46): 13195-13200 [PMID: 26675502 DOI: 10.3748/wjg.v21.i46.13195]
Corresponding Author of This Article
Jae-Young Jang, MD, PhD, Department of Internal Medicine, College of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemoongu, Seoul 130-702, South Korea. jyjang@khu.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 14, 2015; 21(46): 13195-13200 Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.13195
Recurrent gastric neuroendocrine tumors treated with total gastrectomy
Myounghwa Jung, Jung-Wook Kim, Jae-Young Jang, Young Woon Chang, Sun Hee Park, Yong Ho Kim, Youn Wha Kim
Myounghwa Jung, Jung-Wook Kim, Jae-Young Jang, Sun Hee Park, Young Woon Chang, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 130-702, South Korea
Yong Ho Kim, Department of Surgery, College of Medicine, Kyung Hee University, Seoul 130-702, South Korea
Youn Wha Kim, Department of Pathology, College of Medicine, Kyung Hee University, Seoul 130-702, South Korea
Author contributions: Jung M and Kim JW contributed equally to this work; Kim JW, Chang YW, Kim YH, Jang JY, Kim YW and Park SH designed research; Jung M wrote the paper; and Jang JY approved the final version.
Conflict-of-interest statement: All authors declare no conflicts of interest
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jae-Young Jang, MD, PhD, Department of Internal Medicine, College of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemoongu, Seoul 130-702, South Korea. jyjang@khu.ac.kr
Telephone: +82-2-9588200 Fax: +82-2-9681848
Received: February 6, 2015 Peer-review started: February 9, 2015 First decision: April 24, 2015 Revised: June 2, 2015 Accepted: August 28, 2015 Article in press: August 31, 2015 Published online: December 14, 2015
Abstract
Gastric neuroendocrine tumors are rare; however, the incidence has recently increased due to the increasing use of upper endoscopy. Neuroendocrine tumors arise from the excess proliferation of enterochromaffin-like (ECL) cells. The proliferative changes of enterochromaffin cells evolve through a hyperplasia-dysplasia-neoplasia sequence that is believed to underlie the pathogenesis of gastric neuroendocrine tumors. Endoscopic resection is recommended as the initial treatment if the tumor is not in an advanced stage. However, there is no definite guideline for the treatment of recurrent gastric neuroendocrine tumors following endoscopic resection. Here, we report a rare case of gastric neuroendocrine tumors in a 56-year-old male who experienced two recurrences within 11 years after endoscopic resection. The patient finally underwent a total gastrectomy. The pathological features of the resected stomach exhibited the full hyperplasia-dysplasia-neoplasia sequence of the ECL cells in a single specimen.
Core tip: This rare case exhibited the full hyperplasia-dysplasia-neoplasia sequence of enterochromaffin-like cells in a single specimen. This case clarifies the pathogenesis of gastric neuroendocrine tumors. Furthermore, this case revealed that total gastrectomy is a treatment option for patients with recurrent neuroendocrine tumors following excision.
