Yuksel M, Saygili F, Coskun O, Suna N, Kaplan M, Kuzu UB, Kilic ZMY, Ozin YO, Kayacetin E. Treatment of Crohn’s disease and familial Mediterranean fever by leukopheresis: Single shot for two targets. World J Gastroenterol 2015; 21(13): 4078-4081 [PMID: 25852296 DOI: 10.3748/wjg.v21.i13.4078]
Corresponding Author of This Article
Fatih Saygili, MD, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ataturk Bulvari, Kizilay Sokak, 4 Sihhiye, Ankara 06230, Turkey. fsaygili78@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 7, 2015; 21(13): 4078-4081 Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.4078
Treatment of Crohn’s disease and familial Mediterranean fever by leukopheresis: Single shot for two targets
Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin
Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey
Author contributions: Yuksel M collected the data about the case; Saygili F wrote the manuscript; Coskun O collected the digital material about the case; Suna N helped with bibliography; Kaplan M worked on english language and revisions; Kuzu UB worked on data collection and design of the manuscript; Kilic ZMY conceived the study and participated in its design; Ozin YO worked on coordination and helped to draft the manuscript; Kayacetin E worked on design and final correction of the manuscript; all authors read and approved the final manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fatih Saygili, MD, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ataturk Bulvari, Kizilay Sokak, 4 Sihhiye, Ankara 06230, Turkey. fsaygili78@yahoo.com
Telephone: +90-505-5251098 Fax: +90-312-3124120
Received: August 17, 2014 Peer-review started: August 19, 2014 First decision: September 27, 2014 Revised: October 9, 2014 Accepted: November 7, 2014 Article in press: November 11, 2014 Published online: April 7, 2015
Abstract
Coexistence of Crohn's disease (CD) and familial Mediterranean fever (FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.
Core tip: Management of coexisting autoimmune diseases is sometimes problematic because of resistance to standard therapies. Coexistence of Crohn’s disease and familial Mediterranean fever is a rare condition, so the experience about their treatment is lacking. In our report we are sharing our treatment experience of a patient with this coexistence, where the case is refractory to conservative therapies and apheresis was applied as the last choice of treatment. This treatment modality seems to be the first in the literature for these diseases.
