Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2015; 21(12): 3614-3618
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3614
Cholecystectomy does not significantly increase the risk of fatty liver disease
Hong-Gang Wang, Li-Zhen Wang, Hang-Jiang Fu, Peng Shen, Xiao-Dan Huang, Fa-Ming Zhang, Rui Xie, Xiao-Zhong Yang, Guo-Zhong Ji
Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, Jiangsu Province, China
Li-Zhen Wang, Xiao-Dan Huang, Fa-Ming Zhang, Guo-Zhong Ji, Department of Medical Examination Center and Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China
Hang-Jiang Fu, The Cadre Health Care Ward, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China
Author contributions: Wang HG and Wang LZ contributed equally to this work; Wang HG, Zhang FM, Yang XZ and Ji GZ designed the research; Wang HG, Wang LZ, Shen P, Huang XD and Xie R analyzed the data; Wang HG, Fu HJ and Ji GZ wrote the paper.
Ethics approval: This study was reviewed by Nanjing Medical University Institutional Review Board. Ethical approval for this investigation was obtained from the Ethics Committee of Nanjing Medical University.
Informed consent: All participants were informed about the purpose and general procedures of this study and informed consents were signed prior to study enrollment.
Conflict-of-interest: The authors declare that there is no conflict of interest.
Data sharing: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Guo-Zhong Ji, MD, Department of Medical Examination Center and Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, 121 Jiang Jiayuan, Nanjing 210011, Jiangsu Province, China.
Telephone: +86-25-58509996 Fax: +86-25-58509994
Received: October 21, 2014
Peer-review started: October 21, 2014
First decision: October 29, 2014
Revised: November 25, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: March 28, 2015

AIM: To investigate the relationship between cholecystectomy and fatty liver disease (FLD) in a Chinese population.

METHODS: A total of 32428 subjects who had voluntarily undergone annual health checkups in the Second Affiliated Hospital of Nanjing Medical University from January 2011 to May 2013 were included in this study. Basic data collection, physical examination, laboratory examination, and abdominal ultrasound examination were performed.

RESULTS: Subjects undergoing cholecystectomy were associated with greater age, female sex, higher body mass index, and higher levels of systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, and triglycerides. However, no significant differences were found in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, albumin, and serum uric acid. The overall prevalence of FLD diagnosed by ultrasonography was high at 38.4%. The prevalence of FLD was significantly higher for subjects who had undergone cholecystectomy (46.9%) than those who had not undergone cholecystectomy (38.1%; χ2 test, P < 0.001). Cholecystectomy was positively associated with FLD (OR = 1.433, 95%CI: 1.259-1.631). However, after adjusting for possible factors associated with FLD, multivariate regression analysis showed that the association between cholecystectomy and FLD was not statistically significant (OR = 1.096; 95%CI: 0.939-1.279).

CONCLUSION: According to our study results, cholecystectomy may not be a significant risk factor for FLD.

Keywords: Cholecystectomy, Fatty liver disease, Relationship, Cross-sectional study

Core tip: The prevalence of fatty liver disease (FLD) without cholecystectomy was 38.1%, and was up to 46.9% with cholecystectomy, showing an increase in the prevalence of FLD after cholecystectomy. However, no significant association was found between cholecystectomy and FLD after adjusting for multiple related factors. To the best of our knowledge, this is the first study on the correlation between cholecystectomy and FLD in a large Chinese population.