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World J Gastroenterol. Dec 7, 2014; 20(45): 17029-17036
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17029
Chemopreventive effect of apple and berry fruits against colon cancer
Saravana Kumar Jaganathan, Muthu Vignesh Vellayappan, Gayathri Narasimhan, Eko Supriyanto, Dyah Ekashanti Octorina Dewi, Aqilah Leela T Narayanan, Arunpandian Balaji, Aruna Priyadarshini Subramanian, Mustafa Yusof
Saravana Kumar Jaganathan, Eko Supriyanto, Dyah Ekashanti Octorina Dewi, Aqilah Leela T Narayanan, Mustafa Yusof, IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
Muthu Vignesh Vellayappan, Arunpandian Balaji, Aruna Priyadarshini Subramanian, Department of Research and Development, PSNA College of Engineering and Technology, Kothandaraman Nagar, Tamil Nadu, Dindigul 624622, India
Gayathri Narasimhan, Department of Pharmacology, Cinvestav-IPN, Mexico city 07360, Mexico
Author contributions: Jaganathan SK designed the research; Jaganathan SK, Vellayappan MV, Narasimhan G, Balaji A and Subramanian AP collected the literature; Vellayappan MV and Narasimhan G wrote the review in consultation with Jaganathan SK; Narasimhan G, Supriyanto E, Octorina Dewi DE, Narayanan ALT, Arunpandian B and Subramanian AP participated in editing of manuscript by providing suggestions; Yusof M had checked the overall integrity of manuscript during revision by providing suggestions; all the authors verified the final manuscript.
Supported by (in part) Ministry of Higher Education Malaysia with the Grant Vot, No. R.J130000.7809.4F444 and the Ref No. PY/2014/03167; Part of the grant with the Vot, No. 04H93, Ministry of Education was also used for this study
Correspondence to: Saravana Kumar Jaganathan, Senior Lecturer, IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Skudai, Johor Bahru 81310, Malaysia. jaganathaniitkgp@gmail.com
Telephone: +60-7-5558563 Fax: +60-7-5558553
Received: April 11, 2014
Revised: June 16, 2014
Accepted: August 13, 2014
Published online: December 7, 2014
Abstract

Colon cancer arises due to the conversion of precancerous polyps (benign) found in the inner lining of the colon. Prevention is better than cure, and this is very true with respect to colon cancer. Various epidemiologic studies have linked colorectal cancer with food intake. Apple and berry juices are widely consumed among various ethnicities because of their nutritious values. In this review article, chemopreventive effects of these fruit juices against colon cancer are discussed. Studies dealing with bioavailability, in vitro and in vivo effects of apple and berry juices are emphasized in this article. A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell lines. This review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells, and also strives to facilitate clinical studies using these juices in humans in large trials. The conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer.

Keywords: Apple, Berry, Chemoprevention, Colon cancer, Fruit juices, Phytochemicals

Core tip: Colon cancer is one of the leading causes of death worldwide. Chemoprevention of colon cancer using various dietary agents is an area of current interest. This manuscript reviews the chemopreventive potential of apple and berry juices against colon cancer. This work will further promote the importance of dietary fruit juices in colon cancer prevention.