Biosensors for hepatitis B virus detection

doi:10.3748/wjg.v20.i35.12485

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 21, 2014; 20(35): 12485-12492
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12485

Biosensors for hepatitis B virus detection

Chun-Yan Yao, Wei-Ling Fu

Chun-Yan Yao, Wei-Ling Fu, Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Author contributions: Yao CY and Fu WL contributed to this paper.

Supported by National Natural Science Foundation of China, No. 81371885

Correspondence to: Wei-Ling Fu, MD, PhD, Professor, Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, 30 Gaotanyan, Shapingba District, Chongqing 400038, China. weilingfu@yahoo.com

Telephone: +86-23-68754429 Fax: +86-23-65460909

Received: January 4, 2014
Revised: March 1, 2014
Accepted: April 15, 2014
Published online: September 21, 2014

Abstract

A biosensor is an analytical device used for the detection of analytes, which combines a biological component with a physicochemical detector. Recently, an increasing number of biosensors have been used in clinical research, for example, the blood glucose biosensor. This review focuses on the current state of biosensor research with respect to efficient, specific and rapid detection of hepatitis B virus (HBV). The biosensors developed based on different techniques, including optical methods (e.g., surface plasmon resonance), acoustic wave technologies (e.g., quartz crystal microbalance), electrochemistry (amperometry, voltammetry and impedance) and novel nanotechnology, are also discussed.

Keywords: Biosensor, Hepatitis B virus, Diagnosis, Detection, Quartz crystal microbalance

Core tip: This paper reviews the current state of biosensor research with respect to efficient, specific and rapid detection of hepatitis B virus. The biosensors developed based on different techniques, including optical methods (e.g., surface plasmon resonance), acoustic wave technologies (e.g., quartz crystal microbalance), electrochemistry (amperometry, voltammetry and impedance) and novel nanotechnology, are also discussed.