Li JQ, Zhang CQ, Feng KT. Proliferating cell nuclear antigen and P53 protein expression and prognosis in primary liver cancer. World J Gastroenterol 1996; 2(4): 220-222 [DOI: 10.3748/wjg.v2.i4.220]
Corresponding Author of This Article
Jin-Qing Li, MD, Professor, Department of Abdominal Surgery, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, Guangdong Province, China
Article-Type of This Article
Clinical Articles
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World J Gastroenterol. Dec 15, 1996; 2(4): 220-222 Published online Dec 15, 1996. doi: 10.3748/wjg.v2.i4.220
Proliferating cell nuclear antigen and P53 protein expression and prognosis in primary liver cancer
Jin-Qing Li, Chang-Qing Zhang, Kai-Tao Feng
Jin-Qing Li, Chang-Qing Zhang, Kai-Tao Feng, Department of Abdominal Surgery, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, Guangdong Province, China
Jin-Qing Li, graduated from Sun Yat-sen University of Medical Sciences in 1970, Professor in Surgery, MD of Free University, Berlin, Germany. Specialist on clinical diagnosis and treatment of primary liver cancer, having 36 papers published
Author contributions: All authors contributed equally to the work.
Supported by The Foundation of Chinese Education Commission, No. 1993-360.
Correspondence to: Jin-Qing Li, MD, Professor, Department of Abdominal Surgery, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, Guangdong Province, China
Telephone: +86-20-87782287
Received: July 31, 1996 Revised: September 10, 1996 Accepted: October 20, 1996 Published online: December 15, 1996
Abstract
AIM: To study the individual difference and prognosis of primary liver cancer (PLC) after hepatectomy.
METHODS: Two hundred specimens obtained from PLC patients were examined immunohistochemically using anti-P53 and anti-PCNA monoclonal antibodies. The mutations of p53 in exons 5-8 of the gene were examined using the polymerase chain reaction/single-stranded conformational polymorphism (PCR/SSCP) method in 60 of the 200 specimens.
RESULTS: The results showed that the labeling index of proliferating cell nuclear antigen (PCNA) and expression of p53 had a parallel correlation (P < 0.001). The high labeling index of PCNA or overexpression of p53 was associated with a high risk of tumor recurrence, more aggressive growth and poor survival.
CONCLUSION: Immunohistochemical assessment of PCNA and P53 can provide very useful information for the prognosis of PLC.
