Feng GG, Zhou XG, Yu BM. Prevention of liver metastasis by intraperitoneal 5-FU chemotherapy in nude mice inoculated with human colon cancer cells. World J Gastroenterol 1996; 2(3): 134-135 [DOI: 10.3748/wjg.v2.i3.134]
Corresponding Author of This Article
Dr. Guo-Guang Feng, Associate Professor, Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Article-Type of This Article
Experimental Papers
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World J Gastroenterol. Sep 15, 1996; 2(3): 134-135 Published online Sep 15, 1996. doi: 10.3748/wjg.v2.i3.134
Prevention of liver metastasis by intraperitoneal 5-FU chemotherapy in nude mice inoculated with human colon cancer cells
Guo-Guang Feng, Xi-Geng Zhou, Bao-Ming Yu
Guo-Guang Feng, Xi-Geng Zhou, Bao-Ming Yu, Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Guo-Guang Feng, Associate Professor of Surgery has published seven papers.
Author contributions: All authors contributed equally to the work.
Supported by the National Science Foundation of China, No.39270650
Correspondence to: Dr. Guo-Guang Feng, Associate Professor, Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Telephone: +86-21-64370045-6151
Received: July 29, 1996 Revised: August 9, 1996 Accepted: August 23, 1996 Published online: September 15, 1996
Abstract
AIM: To prevent hepatic metastasis by regional adjuvant chemotherapy after radical surgery for colon cancer.
METHODS: A nude mouse model of human colon cancer (HCC) was used to evaluate the prevention of metastasis of HCC cells following the application of early postoperative intraperitoneal (IP) high-dose 5-fluorouracil chemotherapy.
RESULTS: The incidence of liver metastasis was decreased by 40%, and the mean number of metastatic liver nodules was reduced by 50.89%. Compared with controls, 5-FU 40 mg in NS 40 mL/kg IP for 2 consecutive days prolonged mean survival by 48.21%.
CONCLUSION: IP is a promising and effective novel regional adjuvant chemotherapy for the prevention of liver metastasis of HCC cells after radical surgery for colon cancer.
