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World J Gastroenterol. Apr 7, 2013; 19(13): 2122-2125
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2122
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2122
Small intestinal tubular adenoma in a pediatric patient with Turner syndrome
Wen-Juan Tang, Ying Huang, Department of Gastroenterology of Fudan University Children’s Hospital, Shanghai 201102, China
Lian Chen, Department of Pathology of Fudan University Children’s Hospital, Shanghai 201102, China
Shan Zheng, Kui-Ran Dong, Department of Surgery of Fudan University Children’s Hospital, Shanghai 201102, China
Author contributions: Tang WJ and Huang Y contributed equally to this work; Tang WJ and Huang Y designed the research and wrote the paper; Chen L contributed reagents and supplies; Zheng S and Dong KR performed the surgery.
Supported by The 2011 Ministry of Health Key Clinical Speciality Center Project
Correspondence to: Ying Huang, MD, PhD, Department of Gastroenterology of Fudan University Children’s Hospital, 399 Wanyuan Road, Shanghai 201102, China. yhuang815@163.com
Telephone: +86-21-64931990 Fax: +86-21-64931727
Received: October 30, 2012
Revised: January 31, 2013
Accepted: February 5, 2013
Published online: April 7, 2013
Revised: January 31, 2013
Accepted: February 5, 2013
Published online: April 7, 2013
Abstract
Turner syndrome (TS) is a female chromosomal disorder caused by the lack of an X chromosome. The loss of this chromosome may result in the deficiency of tumor-suppressive or DNA repair genes, leading to tumorigenesis. Recombinant human growth hormone (GH) has been popularly used for treatment in TS patients for growth promotion. Although treatment with GH has been correlated with precancerous and cancerous lesions in TS children, its associations with gastric or colonic tumors, especially ileal tubular adenomas, have not been reported frequently. We here report a case of a 16-year-old patient with TS and tubular adenoma of the small intestine. Whether the ileal adenoma was caused by TS itself or GH therapy was discussed.