Brief Article
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World J Gastroenterol. Feb 28, 2012; 18(8): 847-854
Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.847
Interleukin-10-1082G/A polymorphism and acute liver graft rejection: A meta-analysis
Fei Liu, Bo Li, Wen-Tao Wang, Yong-Gang Wei, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Jia-Yin Yang
Fei Liu, Bo Li, Wen-Tao Wang, Yong-Gang Wei, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Liu F and Li B designed the study, collected and analyzed the data and wrote the manuscript; Wang WT and Wei YG collected and analyzed the data and wrote the manuscript; Yan LN analyzed the data and contributed to the discussion; Wen TF and Xu MQ revised the manuscript; Yang JY contributed to the discussion.
Correspondence to: Wen-Tao Wang, Professor, MD, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu 610041, Sichuan Province, China. cdwangwentao@163.com
Telephone: +86-28-85422476 Fax: +86-28-85423724
Received: May 25, 2011
Revised: September 2, 2011
Accepted: October 28, 2011
Published online: February 28, 2012
Abstract

AIM: To investigate the association between interleukin (IL)-10-1082 (G/A) promoter polymorphism and acute rejection (AR) in liver transplant (LT) recipients.

METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95% CIs for IL-10-1082 G/A polymorphism and AR were calculated in a fixed- and a random-effects model as appropriate.

RESULTS: This meta-analysis included seven case-control studies, which comprised 652 cases of LT recipients in which 241 cases developed AR and 411 cases did not develop AR. Overall, the variant A allele was not associated with AR risk when compared with the wild-type G allele (OR = 0.94, 95% CI: 0.64-1.39). Moreover, similar results were observed when the AA genotype was compared with the AG/GG genotype (OR = 1.05, 95% CI: 0.55-2.02). When stratifying for ethnicity, no significant association was observed among either Caucasians or Asians. Because only one study was performed in Asian patients, the result of subgroup analysis by ethnicity would not be reliable for Asians. Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study.

CONCLUSION: This meta-analysis suggests that IL-10-1082 G/A polymorphism may be not associated with AR risk in LT recipients among Caucasians.

Keywords: Liver transplantation, Acute rejection, Interleukin-10, Gene polymorphism, Meta-analysis