Cincibuch J, Mysliveček M, Melichar B, Neoral Č, Metelková I, Zezulová M, Procházková-Študentová H, Flodr P, Zlevorová M, Aujeský R, Cwiertka K. Metastases of esophageal carcinoma to skeletal muscle: Single center experience. World J Gastroenterol 2012; 18(35): 4962-4966 [PMID: 23002370 DOI: 10.3748/wjg.v18.i35.4962]
Corresponding Author of This Article
Bohuslav Melichar, MD, PhD, Professor and Head, Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 77520 Olomouc, Czech Republic. bohuslav.melichar@fnol.cz
Article-Type of This Article
Case Report
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World J Gastroenterol. Sep 21, 2012; 18(35): 4962-4966 Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4962
Metastases of esophageal carcinoma to skeletal muscle: Single center experience
Jan Cincibuch, Miroslav Mysliveček, Bohuslav Melichar, Čestmír Neoral, Iva Metelková, Michaela Zezulová, Hana Procházková-Študentová, Patrik Flodr, Miloslava Zlevorová, René Aujeský, Karel Cwiertka
Jan Cincibuch, Bohuslav Melichar, Michaela Zezulová, Hana Procházková-Študentová, Miloslava Zlevorová, Karel Cwiertka, Department of Oncology, Palacký University Medical School and Teaching Hospital, 77520 Olomouc, Czech Republic
Miroslav Mysliveček, Iva Metelková, Department of Nuclear Medicine, Palacký University Medical School and Teaching Hospital, 77520 Olomouc, Czech Republic
Čestmír Neoral, René Aujeský, 1st Department of Surgery, Palacký University Medical School and Teaching Hospital, 77520 Olomouc, Czech Republic
Patrik Flodr, Department of Pathology, Palacký University Medical School and Teaching Hospital, 77520 Olomouc, Czech Republic
Author contributions: Cincibuch J and Melichar B were involved in the conception of the paper, data acquisition and analysis and coordinated the writing of the manuscript; Mysliveček M, Neoral Č, Metelková I, Zezulová M, Procházková-Študentová H, Flodr P, Zlevorová M, Aujeský R and Cwiertka K participated in the data acquisition and analysis, and contributed to the writing of the manuscript; all authors read and approved the final version of the manuscript.
Supported by Biomedreg CZ.1.05/2.1.00/01.0030
Correspondence to: Bohuslav Melichar, MD, PhD, Professor and Head, Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 77520 Olomouc, Czech Republic. bohuslav.melichar@fnol.cz
Telephone: +420-588-444288 Fax: +420-588-442522
Received: April 9, 2012 Revised: June 26, 2012 Accepted: July 9, 2012 Published online: September 21, 2012
Abstract
Metastases of esophageal carcinoma to the skeletal muscle are rare, but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography (PET/CT). A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between 2006 and 2010 was retrospectively evaluated for the presence of skeletal muscle metastases. Four patients had skeletal muscle metastases of esophageal carcinoma, including two patients with squamous cell carcinoma. In another patient with squamous cell carcinoma of the esophagus and synchronous skeletal muscle metastases, muscle metastases were subsequently shown to be related to second primary pancreatic adenocarcinoma. In all cases, skeletal muscle metastases were the first manifestation of systemic disease. In three patients palliation was obtained with the combination of external beam radiation therapy, systemic chemotherapy or surgical resection. Skeletal muscle metastases are a rare complication of esophageal carcinoma.
