Camus M, Coriat R, Leblanc S, Brezault C, Terris B, Pommaret E, Gaudric M, Chryssostalis A, Prat F, Chaussade S. Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias. World J Gastroenterol 2012; 18(16): 1921-1925 [PMID: 22563172 DOI: 10.3748/wjg.v18.i16.1921]
Corresponding Author of This Article
Dr. Romain Coriat, Gastroenterology and Endoscopy Unit, Cochin Hospital, Assistance Publique-Hopitaux de Paris, Université Paris Descartes, 27, rue du Faubourg Saint Jacques, Sorbone Paris Cité, 75014 Paris, France. romain.coriat@cch.aphp.fr
Article-Type of This Article
Brief Article
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Marine Camus, Romain Coriat, Sarah Leblanc, Catherine Brezault, Elise Pommaret, Marianne Gaudric, Ariane Chryssostalis, Frederic Prat, Stanislas Chaussade, Gastroenterology and Endoscopy Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Sorbone Paris Cité, 75014 Paris, France
Benoit Terris, Pathology Department, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Sorbone Paris Cité, 75014 Paris, France
Author contributions: Camus M and Coriat R contribution equally to this work, drafted the manuscript, edited the endoscopic film statistics, performed the majority of experiments; Leblanc S, Brezault C, Terris B, Pommaret E, Gaudric M, Chryssostalis A and Prat F provided data analysis; Chaussade S co-ordinated the manuscript, provided the collection of endoscopic videos, designed the study and wrote the manuscript.
Correspondence to: Dr. Romain Coriat, Gastroenterology and Endoscopy Unit, Cochin Hospital, Assistance Publique-Hopitaux de Paris, Université Paris Descartes, 27, rue du Faubourg Saint Jacques, Sorbone Paris Cité, 75014 Paris, France. romain.coriat@cch.aphp.fr
Telephone: +33-158-411952 Fax: +33-179-734881
Received: May 6, 2011 Revised: June 27, 2011 Accepted: July 4, 2011 Published online: April 28, 2012
Abstract
AIM: To investigate the mucosal morphology in Barrett’s oesophagus by chromo and magnifying endoscopy.
METHODS: A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy (FICE) for semiological characterization of the mucosal morphology in Barrett’s oesophagus and its neoplastic complications. Upper endoscopy using high definition white light, 2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett’s oesophagus at endoscopy examination. Two patients used as controls had normal endoscopy and histological results. Prospectively, videos were watched blind from histological results by three trained FICE technique endoscopists.
RESULTS: The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined. Videos did not identify irregular vascular patterns using high definition white light endoscopy, while acid acetic-FICE combined visualised one in 86% of cases.
CONCLUSION: Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett’s oesophagus.
