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World J Gastroenterol. Dec 7, 2011; 17(45): 5032-5034
Published online Dec 7, 2011. doi: 10.3748/wjg.v17.i45.5032
Published online Dec 7, 2011. doi: 10.3748/wjg.v17.i45.5032
AG490: An inhibitor of hepcidin expression in vivo
Shu-Ping Zhang, Zhe Wang, Li-Xin Wang, Si-Jin Liu, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
Author contributions: Zhang SP, Wang Z and Wang LX performed experiments; Zhang SP and Liu SJ analyzed the data; Liu SJ designed the study and wrote the manuscript.
Supported by Grants from the Chinese Academy of Sciences, KZCX2-EW-404; and National Natural Science Foundation of China, No. 21077128, 20921063 and 21177151
Correspondence to: Si-Jin Liu, Professor, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. sjliu@rcees.ac.cn
Telephone: +86-10-62849330 Fax: +86-10-62849330
Received: March 21, 2011
Revised: June 21, 2011
Accepted: June 28, 2011
Published online: December 7, 2011
Revised: June 21, 2011
Accepted: June 28, 2011
Published online: December 7, 2011
Abstract
A liver-produced hormone, hepcidin, appears to be the key player in iron metabolism. The overexpression of hepcidin is the underlying cause of anemia of inflammation. The identification of compounds inhibiting hepcidin expression could ameliorate anemia associated with inflammation. In the current study, we have demonstrated for the first time that AG490 significantly abolishes hepcidin expression in mice. Our work represents a novel approach to suppress hepcidin expression for treatment of anemia of inflammation and anemias occurring under other conditions.
Keywords: AG490, Hepcidin, Anemia, Inflammation