Chen J, Liu NN, Li JQ, Yang L, Zeng Y, Zhao XM, Xu LL, Luo X, Wang B, Wang XR. Association between ITGA2 C807T polymorphism and gastric cancer risk. World J Gastroenterol 2011; 17(23): 2860-2866 [PMID: 21734795 DOI: 10.3748/wjg.v17.i23.2860]
Corresponding Author of This Article
Xue-Rong Wang, Professor, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. wangxr@njmu.edu.cn
Article-Type of This Article
Brief Article
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World J Gastroenterol. Jun 21, 2011; 17(23): 2860-2866 Published online Jun 21, 2011. doi: 10.3748/wjg.v17.i23.2860
Association between ITGA2 C807T polymorphism and gastric cancer risk
Jie Chen, Nan-Nan Liu, Jia-Qi Li, Li Yang, Ying Zeng, Xiao-Mei Zhao, Lin-Lin Xu, Xuan Luo, Bin Wang, Xue-Rong Wang
Jie Chen, Nan-Nan Liu, Jia-Qi Li, Ying Zeng, Xiao-Mei Zhao, Lin-Lin Xu, Xuan Luo, Bin Wang, Xue-Rong Wang, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Li Yang, Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Chen J is involved in the study design, conducted polymerase chain reaction-restriction fragment length polymorphism, analyzed the data and wrote the manuscript; Li JQ and Liu NN participated in the study design and extracted genetic DNA from blood samples; Yang L, Zeng Y, Zhao XM, Xu LL and Luo X collected blood samples; Wang B and Wang XR designed and coordinated the study and revised the manuscript.
Supported by The National Natural Science Foundation of China, No. 30873099; Nanjing Medical University start-up research fund for Wang XR; the Natural Science Foundation of education Department, Jiangsu Province, No. 08KJB320004
Correspondence to: Xue-Rong Wang, Professor, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. wangxr@njmu.edu.cn
Telephone: +86-25-86862884 Fax: +86-25-86862884
Received: October 9, 2010 Revised: November 5, 2010 Accepted: November 12, 2010 Published online: June 21, 2011
Abstract
AIM: To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.
METHODS: A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.
RESULTS: The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients.
CONCLUSION: The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
