Brief Article
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World J Gastroenterol. Dec 14, 2010; 16(46): 5895-5900
Published online Dec 14, 2010. doi: 10.3748/wjg.v16.i46.5895
Hepatic blood inflow occlusion without hemihepatic artery control in treatment of hepatocellular carcinoma
Shan Jin, Chao-Liu Dai
Shan Jin, Department of General Surgery, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China
Chao-Liu Dai, Department of Hepatobiliary Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China
Author contributions: Jin S and Dai CL designed the study; Dai CL performed the operations; Jin S wrote the manuscript.
Supported by The Inner Mongolia Science Foundation, Grant No. 2009BS1103
Correspondence to: Shan Jin, MD, Department of General Surgery, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China. jinshangood@yahoo.com.cn
Telephone: +86-471-6637645 Fax: +86-471-6637645
Received: July 28, 2010
Revised: August 25, 2010
Accepted: September 1, 2010
Published online: December 14, 2010
Abstract

AIM: To investigate the clinical significance of hepatic blood inflow occlusion without hemihepatic artery control (BIOwHAC) in the treatment of hepatocellular carcinoma (HCC).

METHODS: Fifty-nine patients with HCC were divided into 3 groups based on the technique used for achieving hepatic vascular occlusion: group 1, vascular occlusion was achieved by the Pringle maneuver (n = 20); group 2, by hemihepatic vascular occlusion (HVO) (n = 20); and group 3, by BIOwHAC (n = 19). We compared the procedures among the three groups in term of operation time, intraoperative bleeding, postoperative liver function, postoperative complications, and length of hospital stay.

RESULTS: There were no statistically significant differences (P > 0.05) in age, sex, pathological diagnosis, preoperative Child’s disease grade, hepatic function, and tumor size among the three groups. No intraoperative complications or deaths occurrred, and there were no significant intergroup differences (P > 0.05) in intraoperative bleeding, hepatic function change 3 and 7 d after operation, the incidence of complications, and length of hospital stay. BIOwHAC and Pringle maneuver required a significantly shorter operation time than HVO; the difference in the serum alanine aminotransferase or aspartate aminotransferase levels before and 1 d after operation was more significant in the BIOwHAC and HVO groups than in the Pringle maneuver group (P < 0.05).

CONCLUSION: BIOwHAC is convenient and safe; this technique causes slight hepatic ischemia-reperfusion injury similar to HVO.

Keywords: Hepatic blood inflow occlusion without hemihepatic artery control; Hepatocellular carcinoma; Intraoperative bleeding; Ischemia-reperfusion injury