Liu JL, Liang Y, Wang ZN, Zhou X, Xing LL. Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis. World J Gastroenterol 2010; 16(43): 5510-5517 [PMID: 21086572 DOI: 10.3748/wjg.v16.i43.5510]
Corresponding Author of This Article
Zhen-Ning Wang, Professor, Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. josieon826@yahoo.com.cn
Article-Type of This Article
Brief Article
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Jia-Li Liu, Zhen-Ning Wang, Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Yuan Liang, Department of Oncology, the Shengjing Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Xin Zhou, Department of Obstetrics and Gynecology, the Shengjing Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Li-Li Xing, Department of Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Author contributions: Liu JL and Liang Y contributed equally to this work; Wang ZN and Zhou X designed the research; Liu JL and Liang Y performed the research; Liu JL and Xing LL analyzed the data; Liu JL and Liang Y wrote the paper.
Supported by National Science Foundation of China, No. 30772137 and No. 30972879; The key laboratory programme of Education Department of Liaoning Province, No. 2008S229
Correspondence to: Zhen-Ning Wang, Professor, Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. josieon826@yahoo.com.cn
Telephone: +86-24-83283556 Fax: +86-24-83283556
Received: April 22, 2010 Revised: June 25, 2010 Accepted: July 2, 2010 Published online: November 21, 2010
Abstract
AIM: To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis.
METHODS: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE, EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR) with 95% confidence interval (CI) was calculated.
RESULTS: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C, -1195A, -1290G, *2430T alleles and *429TT genotype revealed increased risk for GC (OR = 1.71, 95% CI: 1.01-2.90, P = 0.05; OR = 1.58, 95% CI: 1.05-2.38, P = 0.03; OR = 1.55, 95% CI: 1.01-2.39, P = 0.05; OR = 2.62, 95% CI: 1.20-5.73, P = 0.02 and OR = 0.74, 95% CI: 0.59-0.95, P = 0.02, respectively).
CONCLUSION: The -765C, -1195A, -1290G, *2430T alleles and *429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC.
