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World J Gastroenterol. Jul 7, 2009; 15(25): 3173-3177
Published online Jul 7, 2009. doi: 10.3748/wjg.15.3173
Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China
Xiao-Ping Tian, Ying Li, Fan-Rong Liang, Guo-Jie Sun, Jie Yan, Xiao-Rong Chang, Ting-Ting Ma, Shu-Yuan Yu, Xu-Guang Yang
Xiao-Ping Tian, Ying Li, Fan-Rong Liang, Ting-Ting Ma, Shu-Yuan Yu, Xu-Guang Yang, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
Guo-Jie Sun, Hubei College of Traditional Chinese Medicine, Wuhan 430065, Hubei Province, China
Jie Yan, Xiao-Rong Chang, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China
Author contributions: Tian XP and Liang FR contributed equally to this work; Tian XP, Li Y and Liang FR designed the study; Tian XP, Sun GJ, Yan J, Chang XR and Yang XG performed the study; Tian XP, Ma TT and Yu SY wrote and revised the manuscript.
Correspondence to: Fan-Rong Liang, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China. acuresearch@126.com
Telephone: +86-28-6180006
Fax: +86-28-87790472
Received: March 13, 2009
Revised: May 13, 2009
Accepted: May 20, 2009
Published online: July 7, 2009
Abstract

AIM: To assess the reliability and validity of the translated version of Nepean Dyspepsia Index (NDI) in Chinese patients with documented functional dyspepsia (FD).

METHODS: The translation process included forward translation, back translation, pretest and cross-cultural adaptation. Reliability and validity of the translated version were examined by asking 300 subjects to complete the Chinese version of the NDI. The mean age of subjects was 39.24 years and 68.7% of the subjects were women. Internal consistency analysis with Cronbach’s α was performed to test the reliability. Correlation analysis was used to assess the content validity. Factor analysis and structural equation models were used to assess the construct validity.

RESULTS: The Cronbach’s α coefficients ranged 0.833-0.960, well above the acceptable level of 0.70. Correlation analysis showed that each item had a strong correlation with the corresponding domain, but a weak correlation with other domains. Confirmatory factor analysis indicated that the comparative fit index was 0.94, higher than the acceptable level of 0.90.

CONCLUSION: The Chinese version of the NDI is a reliable and valid scale for measuring health-related quality of life and disease severity in Chinese patients with FD.

Keywords: Nepean Dyspepsia Index; Functional dyspepsia; Health-related quality of life; Validation studies; Questionaires