Case Report
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jun 7, 2009; 15(21): 2669-2671
Published online Jun 7, 2009. doi: 10.3748/wjg.15.2669
Ceftriaxone-induced toxic hepatitis
Erdal Peker, Eren Cagan, Murat Dogan
Erdal Peker, Eren Cagan, Murat Dogan, Department of Pediatrics, Medical University of Yuzuncu Yil, 65100 Van, Turkey
Author contributions: Peker E had primary responsibility for protocol development, patient screening, enrollment, outcome assessement, preliminary data analysis, and writing the manuscript; Cagan E and Dogan M participated in the analytic framework for the study, and contributed to the writing of the manuscript.
Correspondence to: Erdal Peker, MD, Department of Pediatrics, Medical University of Yuzuncu Yil, 65100 Van, Turkey. pekererdal@hotmail.com
Telephone: +90-532-7116054
Fax: +90-432-2155281
Received: March 3, 2009
Revised: April 23, 2009
Accepted: April 30, 2009
Published online: June 7, 2009
Abstract

Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of a long half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a frequent choice in the treatment of childhood infections. Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels, along with three cases of hepatitis caused by ceftriaxone. Here, we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis.

Keywords: Hepatitis, Toxic, Ceftriaxone, Children, Drug