Tsuchiya A, Imai M, Kamimura H, Togashi T, Watanabe K, Seki KI, Ishikawa T, Ohta H, Yoshida T, Kamimura T. Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracil. World J Gastroenterol 2009; 15(14): 1779-1781 [PMID: 19360925 DOI: 10.3748/wjg.15.1779]
Corresponding Author of This Article
Atsunori Tsuchiya, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. atsunori@med.niigata-u.ac.jp
Article-Type of This Article
Case Report
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Atsunori Tsuchiya, Michitaka Imai, Hiroteru Kamimura, Kouji Watanabe, Kei-ichi Seki, Toru Ishikawa, Hironobu Ohta, Toshiaki Yoshida, Tomoteru Kamimura, Department of Gastroenterology, Saiseikai Niigata Second Hospital, Nishi-Ku, Teraji 280-7, Niigata 950-1104, Japan
Atsunori Tsuchiya, Hiroteru Kamimura, Tadayuki Togashi, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan
Author contributions: Tsuchiya A, Imai M, and Togashi T performed research; Kamimura H, Watanabe K, Seki K, Ishikawa T, Ohta H, Yoshida T and Kamimura T designed research. Tsuchiya A wrote the paper.
Correspondence to: Atsunori Tsuchiya, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. atsunori@med.niigata-u.ac.jp
Telephone: +81-25-2272207
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Received: December 23, 2008 Revised: March 2, 2009 Accepted: March 9, 2009 Published online: April 14, 2009
Abstract
We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year-old man was diagnosed with multiple lung metastases of HCC 7 mo after partial hepatectomy for HCC. Oral UFT-E was given daily and docetaxel and CDDP were given intra-arterially (administered just before the bronchial arteries) every 2 wk via a subcutaneous injection port. One month after starting chemotherapy, levels of tumor marker, protein induced by vitamin K absence II (PIVKA-II), decreased rapidly, and after a further month, chest X-ray and computed tomography revealed the complete disappearance of multiple liver metastases. Two years after the combined chemotherapy, HCC recurred in the liver and was treated but no pulmonary recurrence occurred. In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC.
