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World J Gastroenterol. Feb 14, 2008; 14(6): 908-912
Published online Feb 14, 2008. doi: 10.3748/wjg.14.908
H pylori eradication: A randomized prospective study of triple therapy with or without ecabet sodium
Hyung Wook Kim, Gwang Ha Kim, Jong Yun Cheong, Ung Suk Yang, Seung Keun Park, Chul Soo Song, Dae Hwan Kang, Geun Am Song
Hyung Wook Kim, Ung Suk Yang, Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Korea
Gwang Ha Kim, Jong Yun Cheong, Chul Soo Song, Dae Hwan Kang, Geun Am Song, Department of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Korea
Seung Keun Park, Department of Internal Medicine, Maryknoll Hospital, Busan, Korea
Author contributions: Kim HW and Kim GH contributed equally to this work; Kim GH, Cheong JY and Song GA designed the research; Kim HW, Kim GH, Cheong JY, Yang US, Park SK and Song CS performed the research; Kim GH, and Kang DH analyzed the data; and Kim HW and Kim GH wrote the paper.
Correspondence to: Gwang Ha Kim, Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, 1-10 Ami-dong, Seo-Gu, Busan 602-739, Korea. doc0224@pusan.ac.kr
Telephone: +82-51-2407869
Fax: +82-51-2448180
Received: September 14, 2007
Revised: November 22, 2007
Published online: February 14, 2008

AIM: To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate.

METHODS: Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative 13C-urea breath test 6-8 wk after completion of treatment.

RESULTS: After completion of therapy, 194/257 patients showed negative 13C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups.

CONCLUSION: Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori.

Keywords: H pylori, Eradication, Triple therapy, Ecabet sodium