α-Lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats

doi:10.3748/wjg.v11.i31.4883

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 31

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2276)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-1) series.

Item

Count

PDF

238

HTML

1769

Figures (1-2)

146

Tables (1-1)

123

Sum=2276

Aug 21, 2005 (publication date) through Apr 16, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Gastroenterol. Aug 21, 2005; 11(31): 4883-4885
Published online Aug 21, 2005. doi: 10.3748/wjg.v11.i31.4883

α-Lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats

Sung-Joo Park, Sang-Wan Seo, Ok-Sun Choi, Cheung-Seog Park

Sung-Joo Park, Sang-Wan Seo, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University ^#1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea

Ok-Sun Choi, Cheung-Seog Park, Department of Microbiology, College of Medicine, Kyung Hee University ^#1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea

Author contributions: All authors contributed equally to the work.

Supported by the Next Generation Growth Engine Program grant from the Ministry of Science and Technology (2004-00075), South Korea

Correspondence to: Dr. Cheung-Seog Park, Department of Microbiology, College of Medicine, Kyung Hee University ^#1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea

Telephone: +82-2-961-0294 Fax: +82-2-962-6189

Received: January 11, 2005
Revised: January 23, 2005
Accepted: January 26, 2005
Published online: August 21, 2005

Abstract

AIM: α-Lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of α-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats.

METHODS: ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 μg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase, amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis.

RESULTS: ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However, the secretion of IL-1β, IL-6, and TNF-α were comparable in CCK octapeptide-induced acute pancreatitis.

CONCLUSION: ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.

Keywords: α-Lipoic acid, Acute pancreatitis, Proinflammatory cytokines, Cholecystokinin