Clinical Research
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2005; 11(31): 4843-4847
Published online Aug 21, 2005. doi: 10.3748/wjg.v11.i31.4843
Value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas using automated biopsy gun
Li Li, Qiu-Liang Wu, Li-Zhi Liu, Yun-Xian Mo, Chuan-Miao Xie, Lie Zheng, Lin Chen, Pei-Hong Wu
Li Li, Li-Zhi Liu, Yun-Xian Mo, Chuan-Miao Xie, Lie Zheng, Lin Chen, Pei-Hong Wu, State Key Laboratory of Oncology in Southern China, Imaging Diagnosis and Interventional Center, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Qiu-Liang Wu, State Key Laboratory of Oncology in Southern China, Department of Pathology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Pei-Hong Wu, Imaging Diagnosis and Interventional Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China. jrkzl@gzsums.edu.cn
Telephone: +86-20-87343270 Fax: +86-20-87343392
Received: December 2, 2004
Revised: February 15, 2005
Accepted: February 18, 2005
Published online: August 21, 2005
Abstract

AIM: To evaluate the value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas.

METHODS: From January 1999 to October 2004, CT-guided core-needle biopsies were performed in 80 patients with suspected malignant lymphoma. Biopsies were performed with an 18-20 G biopsy-cut (CR Bard, Inc., Covington, GA, USA) needle driven by a spring-loaded Bard biopsy gun.

RESULTS: A definite diagnosis and accurate histological subtype were obtained in 61 patients with a success rate of 76.25% (61/80). Surgical sampling was performed in 19 patients (23.75%) with non-diagnostic core-needle biopsies. The success rate of CT-guided core-needle biopsy varied with the histopathologic subtypes in our group. The relatively high success rates of core-needle biopsy were noted in diffuse large B-cell non-Hodgkin’s lymphoma (NHL, 88.89%) and peripheral T-cell NHL (90%). However, the success rates were relatively low in anaplastic large cell (T/null cell) lymphoma (ALCL, 44.44%) and Hodgkin’s disease (HD, 28.57%) in our group.

CONCLUSION: CT-guided core-needle biopsy is a reliable means of diagnosing and classifying malignant lymphomas, and can be widely applied in the management of patients with suspected malignant lymphoma.

Keywords: Malignant lymphoma, Biopsy, Computed tomography