Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2005; 11(29): 4566-4569
Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4566
Circulating adhesion molecules in patients with virus-related chronic diseases of the liver
Cosimo Marcello Bruno, Claudio Sciacca, Danila Cilio, Gaetano Bertino, Anna Elisa Marchese, Gaetana Politi, Lucia Chinnici
Cosimo Marcello Bruno, Claudio Sciacca, Danila Cilio, Gaetano Bertino, Department of Internal Medicine and Systemic Diseases, University of Catania, Italy
Anna Elisa Marchese, Gaetana Politi, Lucia Chinnici, Clinical Laboratory Analysis, S. Bambino Hospital, Catania, Italy
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Cosimo Marcello Bruno, Dip. Medicina Interna e Patologie Sistemiche Osp. S. Marta, via G. Clementi 36, Catania 95124, Italy. cmbruno@unict.it
Telephone: +39-95-7435677
Received: October 5, 2004
Revised: December 20, 2004
Accepted: December 23, 2004
Published online: August 7, 2005
Abstract

AIM: In the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site. Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage.

METHODS: Circulating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R&D System Co., Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer.

RESULTS: LC patients had significantly higher ICAM-1 values than CH patients (38.567.4 ng/mL vs 20.896.42 ng/mL; P<0.001) and these ones had significantly higher values than controls (12.921.08 ng/mL; P<0.001). In CH group, ICAM-1 levels were significantly related to inflammatory activity (P = 0.041) and ALT values (r = 0.77; P<0.05). VCAM-1 values were significantly increased only in LC patients (P<0.001) and related to severity of liver impairment.

CONCLUSION: These findings suggest that the determination of serum ICAM-1 can be considered as an additional useful marker of hepatocellular necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator of liver fibrogenesis and severity of disease in cirrhosis.

Keywords: ICAM-1; VCAM-1; Chronic liver diseases; Hepatocellular necrosis; Liver fibrosis