Gastric Cancer
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2005; 11(25): 3842-3845
Published online Jul 7, 2005. doi: 10.3748/wjg.v11.i25.3842
Use of Fourier-transform infrared spectroscopy to rapidly diagnose gastric endoscopic biopsies
Qing-Bo Li, Xue-Jun Sun, Yi-Zhuang Xu, Li-Min Yang, Yuan-Fu Zhang, Shi-Fu Weng, Jing-Sen Shi, Jin-Guang Wu
Qing-Bo Li, Yi-Zhuang Xu, Li-Min Yang, Yuan-Fu Zhang, Shi-Fu Weng, Jin-Guang Wu, The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Xue-Jun Sun, Jing-Sen Shi, Department of General Surgery, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30371604 and State Key Project of China, No. 2002CCA01900
Correspondence to: Jin-Guang Wu, the State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. wujg@pku.edu.cn
Telephone: +86-10-62757951 Fax: +86-10-62751708
Received: July 9, 2004
Revised: September 3, 2004
Accepted: September 9, 2004
Published online: July 7, 2005
Abstract

AIM: To determine if Fourier-transform infrared (FT-IR) spectroscopy of endoscopic biopsies could accurately diagnose gastritis and malignancy.

METHODS: A total of 123 gastroscopic samples, including 11 cases of cancerous tissues, 63 cases of chronic atrophic gastritis tissues, 47 cases of chronic superficial gastritis tissues and 2 cases of normal tissues, were obtained from the First Hospital of Xi’an Jiaotong University, China. A modified attenuated total reflectance (ATR) accessory was linked to a WQD-500 FT-IR spectrometer for spectral measurement followed by submission of the samples for pathologic analysis. The spectral characteristics for different types of gastroscopic tissues were summarized and correlated with the corresponding pathologic results.

RESULTS: Distinct differences were observed in the FT-IR spectra of normal, atrophic gastritis, superficial gastritis and malignant gastric tissues. The sensitivity of FT-IR for detection of gastric cancer, chronic atrophic gastritis and superficial gastritis was 90.9%, 82.5%, 91.5%, and specificity was 97.3%, 91.7%, 89.5% respectively.

CONCLUSION: FT-IR spectroscopy can distinguish gastric inflammation from malignancy.

Keywords: Fourier-transform infrared spectroscopy, Gastric endoscope, Gastric cancer, Chronic gastritis, Spectral analysis, Infrared detection