Liver Cancer
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 1, 2004; 10(15): 2201-2204
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2201
Analysis of clinical effect of high-intensity focused ultrasound on liver cancer
Chuan-Xing Li, Guo-Liang Xu, Zhen-You Jiang, Jian-Jun Li, Guang-Yu Luo, Hong-Bo Shan, Rong Zhang, Yin Li
Chuan-Xing Li, Guo-Liang Xu, Jian-Jun Li, Guang-Yu Luo, Hong-Bo Shan, Rong Zhang, Yin Li, Department of HIFU, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China
Zhen-You Jiang, Medical College, Jinan University, Guangzhou 510632, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Chuan-Xing Li, Department of HIFU, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China. lichx@163.net
Telephone: +86-20-87343381 Fax: +86-20-87342737
Received: December 10, 2003
Revised: December 23, 2003
Accepted: January 15, 2004
Published online: August 1, 2004
Abstract

AIM: To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.

METHODS: HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment.

RESULTS: After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95 ± 44) U/L and AST (114 ± 58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.

CONCLUSION: HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.

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