Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats

doi:10.3748/wjg.v10.i13.1967

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 1, 2004; 10(13): 1967-1970
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1967

Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats

Ji-Feng Wang, Yan-Xia Guo, Jan-Zhao Niu, Juan Liu, Ling-Qiao Wang, Pei-Heng Li

Ji-Feng Wang, Yan-Xia Guo, Jan-Zhao Niu, Juan Liu, Ling-Qiao Wang, Pei-Heng Li, Department of Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30330220 and the Natural Science Foundation of Beijing, No. 7032024

Correspondence to: Professor Ji-Feng Wang, Department of Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China

Telephone: +86-10-64286995 Fax: +86-10-64286995

Received: September 15, 2003
Revised: December 3, 2003
Accepted: December 10, 2003
Published online: July 1, 2004

Abstract

AIM: To study the effects of Radix Puerariae flavones (RPF) on liver lipid metabolism in ovariectomized (OVX) rats.

METHODS: Forty adult female Wistar rats were randomly divided into four groups: OVX group; sham-OVX group; OVX + estrogen group and OVX + RPF group. One week after operation rats of the first two groups were treated with physiological saline, rats of OVX + estrogen group with estrogen (1 mg/kg·b.w.) and rats of OVX + RPF group with RPF (100 mg/kg·b.w.), respectively for 5 weeks. After the rats were killed, their body weight, the weight of the abdominal fat and uterus were measured, and the levels of total cholesterol (TC) and triglyceride (TG) in liver homogenate were determined.

RESULTS: Compared with the sham-OVX group, the body mass of the rats in OVX group was found increased significantly; more abdominal fat in store; TC and TG in liver increased and uterine became further atrophy. As a result, the RPF was found to have an inhibitive action on those changes of various degrees.

CONCLUSION: RPF has estrogen-like effect on lipid metabolism in liver and adipose tissue.

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