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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2024; 30(10): 1420-1430
Published online Mar 14, 2024. doi: 10.3748/wjg.v30.i10.1420
Published online Mar 14, 2024. doi: 10.3748/wjg.v30.i10.1420
Preliminary exploration of animal models of congenital choledochal cysts
Shu-Hao Zhang, Yue-Bin Zhang, Duo-Te Cai, Tao Pan, Ken Chen, Yi Jin, Wen-Juan Luo, Zong-Wei Huang, Qing-Jiang Chen, Zhi-Gang Gao, Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Zhang SH designed and performed the research and wrote the paper; Gao ZG, Zhang YB, and Cai DT designed the research and supervised the report; Chen K, Jin Y, Luo WJ, and Huang ZW designed the research and contributed to the analysis; Chen QJ and Pan T provided clinical advice and supervised the report.
Supported by the Key R&D Program of Zhejiang , No. 2023C03029 ; Health Science and Technology Plan of Zhejiang Province , No. 2022RC201 ; and Zhejiang Provincial Natural Science Foundation Project , No. LY20H030007 .
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of The Children’s Hospital, Zhejiang University School of Medicine (approval No. 2022-IRB-108). Prior to inclusion in this study, written informed consent was obtained from all subjects.
Institutional animal care and use committee statement: The protocol of the animal study was approved by the Institutional Animal Care and Use Committee of Laboratory Animal Center of Zhejiang University (approval No. ZJU20230273).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Gang Gao, PhD, Chief Doctor, Department of General Surgery, Children’s Hospital, Zhejiang University School of Medicine, No. 3333 Binsheng Road, Binjiang District, Hangzhou 310000, Zhejiang Province, China. ebwk@zju.edu.cn
Received: October 17, 2023
Peer-review started: October 17, 2023
First decision: January 15, 2024
Revised: January 17, 2024
Accepted: February 21, 2024
Article in press: February 21, 2024
Published online: March 14, 2024
Peer-review started: October 17, 2023
First decision: January 15, 2024
Revised: January 17, 2024
Accepted: February 21, 2024
Article in press: February 21, 2024
Published online: March 14, 2024
Core Tip
Core Tip: Recent studies have focused more on clinical issues rather than etiology and pathogenesis of choledochal cyst (CC). In this study, our partial ligation of the bile duct of juvenile rats successfully simulated the pathological processes of recanalization after incomplete obstruction of the distal bile duct. The postoperative disease progression of this model was more consistent with the natural course of CC formation which may assist in further basic research on the pathogenesis of CC.