Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2022; 28(13): 1347-1361
Published online Apr 7, 2022. doi: 10.3748/wjg.v28.i13.1347
Increased prognostic value of clinical–reproductive model in Chinese female patients with esophageal squamous cell carcinoma
Dong-Yun Zhang, Jian-Wei Ku, Xue-Ke Zhao, Hai-Yan Zhang, Xin Song, Hong-Fang Wu, Zong-Min Fan, Rui-Hua Xu, Duo You, Ran Wang, Ruo-Xi Zhou, Li-Dong Wang
Dong-Yun Zhang, Xue-Ke Zhao, Xin Song, Zong-Min Fan, Rui-Hua Xu, Duo You, Ran Wang, Li-Dong Wang, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Dong-Yun Zhang, Hong-Fang Wu, Department of Pathology, Nanyang Medical College, Nanyang 473061, Henan Province, China
Jian-Wei Ku, Department of Endoscopy, The Third Affiliated Hospital, Nanyang Medical College, Nanyang 473061, Henan Province, China
Hai-Yan Zhang, Department of Pathology, The First Affiliated Hospital, Nanyang Medical College, Nanyang 473061, Henan Province, China
Duo You, Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450052, Henan Province, China
Ruo-Xi Zhou, Department of Biology, University of Richmond, Richmond, VA 23173, United States
Author contributions: Wang LD and Zhang DY designed and wrote the paper; Ku JW, Xu RH, Wang R, Wu HF, and Fan ZM performed the data collection, interpretation and follow-up; Zhang DY, Zhao XK, Zhou RX, and Song X contributed to the data analysis; all authors performed the final approvlement.
Supported by National Natural Science Foundation of China, No. 81872032 and No. U1804262; National Key R&D Program of China, No. 2016YFC0901403; High-Tech Key Projects of High School of Henan Province, No. 20B320011; and High-Tech Key Projects of Science and Technology of Henan Province Government, No. 202102310366.
Institutional review board statement: This research content and process of the project followed the international and national ethical requirements for biomedical research and agreed to publish. The study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University and Institutional Review Board of the First Affiliated Hospital of Nanyang Medical College.
Conflict-of-interest statement: We have no potential conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Dong Wang, MD, PhD, Professor, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwangpaper2018@126.com
Received: October 25, 2021
Peer-review started: October 25, 2021
First decision: January 9, 2022
Revised: January 21, 2022
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: April 7, 2022
Core Tip

Core Tip: In China, some female patients with esophageal squamous cell carcinoma (ESCC), even with the same tumor-node-metastasis (TNM) stage, have significantly different overall survival (OS) time. The prognostic value of the TNM system has been challenged due to its unsatisfactory discriminative ability. A new prognostic nomogram that combines clinical and reproductive features was developed and validated in this study. Compared with the clinical model and TNM stage, clinical–reproductive model has incremental prognostic value in predicting OS in Chinese female patients with ESCC, which can help clinicians to make individual treatment and medical decisions.