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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2017; 23(45): 8082-8089
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8082
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8082
Impact of inflammatory bowel disease activity and thiopurine therapy on birth weight: A meta-analysis
Begoña Gonzalez-Suarez, Shreyashee Sengupta, Alan C Moss, Division of Gastroenterology, Inflammatory Bowel Disease Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
Author contributions: Gonzalez-Suarez B, Sengupta S acquisition of data, data analysis, drafting the manuscript; Moss AC study concept and design, critical revision of the manuscript for important intellectual content, statistical analysis, study supervision.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alan C Moss, MD, Division of Gastroenterology, Inflammatory Bowel Disease Center, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States. amoss@bidmc.harvard.edu
Telephone: +1-617-667-3197
Received: May 27, 2017
Peer-review started: June 1, 2017
First decision: June 23, 2017
Revised: July 7, 2017
Accepted: August 9, 2017
Article in press: October 24, 2017
Published online: December 7, 2017
Peer-review started: June 1, 2017
First decision: June 23, 2017
Revised: July 7, 2017
Accepted: August 9, 2017
Article in press: October 24, 2017
Published online: December 7, 2017
Core Tip
Core tip: There are conflicting data on the impact of disease activity and thiopurine use on birth weight in pregnant women with inflammatory bowel disease. The individual impact of these factors in low birth weight (LBW) and small gestational age (SGA) has not been systematically evaluated to date. For these reasons, we performed a meta-analysis to identify the effect of disease activity or thiopurine use on the rates of LBW and SGA in these patients. Since many women become non-adherent to medications during pregnancy, for fear of a negative effect on the fetus, further information would be useful in counseling women.