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World J Gastroenterol. Jun 21, 2014; 20(23): 7197-7206
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7197
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7197
Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity
Xia Jiang, Tatsuo Kanda, Shuang Wu, Masato Nakamura, Tatsuo Miyamura, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8677, Japan
Shingo Nakamoto, Department of Molecular Virology, Graduate School of Medicine, Chiba University, Chiba 260-8677, Japan
Arup Banerjee, Vaccine and Infectious Disease Research Center and Translational Health Science and Technology Institute, Gurgaon-122016, Haryana, India
Author contributions: Jiang X, Kanda T, Wu S, Nakamura M, Miyamura T, Nakamoto S, Banerjee A and Yokosuka O contributed to this paper.
Supported by Grants for “Asia-Oceania Collaborative Research Grants” from Kanae Foundation for the Promotion of Medical Science (to Kanda T); Grants for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (to Kanda T)
Correspondence to: Tatsuo Kanda, MD, PhD, Associate Professor, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kandat-cib@umin.ac.jp
Telephone: +81-43-2262086 Fax: +81-43-2262088
Received: October 17, 2013
Revised: December 11, 2013
Accepted: January 3, 2014
Published online: June 21, 2014
Revised: December 11, 2013
Accepted: January 3, 2014
Published online: June 21, 2014
Core Tip
Core tip: Hepatitis B virus (HBV) is the leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma in the world. HBV could interact with the host’s innate and adaptive immune responses to establish chronic infection. HBV also interacts with Toll-like receptors (TLRs) and TLR signaling pathways, and regulates host immune responses through the regulation of microRNAs (miRNAs) to some extent. This article focuses on the involvement of miRNA in the association between HBV and TLR signaling pathways and reviews the miRNAs involved in HBV infection.