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World J Gastroenterol. Dec 28, 2013; 19(48): 9425-9431
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9425
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9425
Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer
Xin Jiao, Hai-Ning Zhi, Xiao-Man Liu, Chen-Hao Liu, Department of General Surgery, the First Central Clinical School, Tianjin Medical University, Tianjin 300192, China
Hong-Jun Lu, Da-Peng Zhang, Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Naikai Clinical School, Tianjin Medical University, Tianjin 300100, China
Mi-Mi Zhai, Department of Gastroenterology, Weifang People’s Hospital, Weifang 261041, Shandong Province, China
Zhi-Jun Tan, Department of General Surgery, Tianjin First Central Hospital, Tianjin 300192, China
Author contributions: Jiao X performed the majority of experiments and wrote the manuscript; Lu HJ, Zhai MM, Zhi HN, Liu XM and Liu CH designed the research and revised the manuscript; Zhang DP instructed the preparation of the manuscript; Tan ZJ provided experimental guidance.
Correspondence to: Da-Peng Zhang, PhD, MD, Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Naikai Clinical School, Tianjin Medical University, No. 6, Changjiang Road, Nankai District, Tianjin 300100, China. dapeng721115@126.com
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Received: August 18, 2013
Revised: October 15, 2013
Accepted: November 1, 2013
Published online: December 28, 2013
Revised: October 15, 2013
Accepted: November 1, 2013
Published online: December 28, 2013
Core Tip
Core tip: The study examined the clinicopathologic and prognostic significance of kallikrein gene 10 (KLK10) expression in gastric cancer. Based on collective findings, we hypothesize that KLK10 expression in gastric cancer tissues may have prognostic/predictive value in patients with gastric cancer. KLK10 expression is an independent biomarker for predicting unfavorable prognosis in patients with gastric cancer.