8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of &beta;-catenin

doi:10.3748/wjg.v19.i43.7680

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Nov 21, 2013; 19(43): 7680-7695
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7680

8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin

Mei-Fang Quan, Li-Hong Xiao, Zhi-Hong Liu, Hui Guo, Kai-Qun Ren, Fei Liu, Jian-Guo Cao, Xi-Yun Deng

Mei-Fang Quan, Li-Hong Xiao, Kai-Qun Ren, Fei Liu, Jian-Guo Cao, Xi-Yun Deng, Medical College, Hunan Normal University, Changsha 410013, Hunan Province, China

Zhi-Hong Liu, Hui Guo, Department of pathology, Hunan Provincial Tumor Hospital, Changsha 410013, Hunan Province, China

Author contributions: Quan MF and Xiao LH contributed equally to this work; Quan MF, Xiao LH, Liu ZH, Guo H, Ren KQ and Liu F performed the majority of experiments; Cao JG designed the study and wrote the manuscript; Deng XY participated in the study and helped to draft the manuscript.

Supported by National Natural Science Foundation of China, No. 81172375; and Scientific Research Fund of Hunan Normal University, No. 81105

Correspondence to: Jian-Guo Cao, Professor, Medical College, Hunan Normal University, Yuelu District, Changsha 410013, Hunan Province, China. caojianguo2005@126.com

Telephone: +86-731-88912434 Fax: +86-731-88912417

Received: May 22, 2013
Revised: September 13, 2013
Accepted: September 16, 2013
Published online: November 21, 2013

Core Tip

Core tip: We successfully obtained liver cancer stem cells (LCSCs) from the liver cancer MHCC97 cell line by employing the combination of magnetic activated cell sorting and tumorsphere culture. We showed for the first time that 8-bromo-7-methoxychrysin (BrMC), a synthetic analogue of chrysin, could preferentially inhibit proliferation and self-renewal, suppress epithelial-mesenchymal transition and invasion of LCSCs, and further eradicate LCSCs in vivo. The results of this study support the use of BrMC for liver cancer chemoprevention or chemotherapy.