Effects of Zuogui Wan on neurocyte apoptosis and down-regulation of TGF-&beta;1 expression in nuclei of arcuate hypothalamus of monosodium glutamate -liver regeneration rats

doi:10.3748/wjg.v10.i19.2823

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Oct 1, 2004 (publication date) through Apr 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Oct 1, 2004; 10(19): 2823-2826
Published online Oct 1, 2004. doi: 10.3748/wjg.v10.i19.2823

Effects of Zuogui Wan on neurocyte apoptosis and down-regulation of TGF-β₁ expression in nuclei of arcuate hypothalamus of monosodium glutamate -liver regeneration rats

Han-Min Li, Xiang Gao, Mu-Lan Yang, Jia-Jun Mei, Liu-Tong Zhang, Xing-Fan Qiu

Han-Min Li, Xiang Gao, Hepatopathy Institute, Affiliated Hospital of Hubei Traditional Chinese Medicine College, Wuhan 430061, Hubei Province, China

Mu-Lan Yang, Ultramicropathology Laboratory, Tongji Medicine College, Huazhong Scientific University, Wuhan 430030, Hubei Province, China

Jia-Jun Mei, Liu-Tong Zhang, Xing-Fan Qiu, Hubei Traditional Chinese Medicine College, Wuhan 430061, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Supported by National Natural Science Foundation of China, No. 30271562 and Natural Science Foundation of Huibei Province, China, No.2001ABB171

Correspondence to: Han-Min Li, Hepatopathy Institute, Affiliated Hospital of Hubei Traditional Chinese Medicine College, Wuhan 430061, Hubei Province, China

Telephone: +86-27-88929180 Fax: +86-27-88929180

Received: August 8, 2003
Revised: October 15, 2003
Accepted: October 22, 2003
Published online: October 1, 2004

Abstract

AIM: To inquire into the effects and mechanism of Zuogui Wan (Pills for Kidney Yin) on neurocyte apoptosis in nuclei of arcuate hypothalamus (ARN) of monosodium glutamate (MSG)-liver regeneration rats, and the mechanism of liver regeneration by using optic microscope, electron microscope and in situ end labeling technology to adjust nerve-endocrine-immunity network.

METHODS: Neurocyte apoptosis in ARN of the experiment rats was observed by using optic microscope, electron microscope and in situ end labeling technology. Expression of TGF-β₁ in ARN was observed by using immunohistochemistry method.

RESULTS: The expression of TGF-β₁ in rats of model group was increased with the increase of ARN neurocyte apoptosis index (AI) (t = 8.3097, 12.9884, P < 0.01). As compared with the rats of model group, the expression of TGF-β₁ in rats of Zuogui Wan treatment group was decreased with the significant decrease of ARN neurocyte apoptosis (t = 4.5624, 11.1420, P < 0.01).

CONCLUSION: Brain neurocyte calcium ion overexertion and TGF-β₁ protein participate in the adjustment and control of ARN neurocyte apoptosis in MSG-liver regeneration-rats. Zuogui Wan can prevent ARN neurocyte apoptosis of MSG-liver regeneration in rats by down-regulating the expression of TGF-β₁, and influence liver regeneration through adjusting nerve-endocrine-immune network.

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