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World J Meta-Anal. Nov 26, 2014; 2(4): 179-185
Published online Nov 26, 2014. doi: 10.13105/wjma.v2.i4.179
Published online Nov 26, 2014. doi: 10.13105/wjma.v2.i4.179
Meta-analysis of bivariate P values
Mehmet Kocak, Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38105, United States
Author contributions: Kocak M solely contributed to this paper.
Correspondence to: Mehmet Kocak, PhD, Assistant Professor, Department of Preventive Medicine, University of Tennessee Health Sciences Center, 66 N. Pauline Street Office 626, Memphis, TN 38105, United States. mkocak1@uhtsc.edu
Telephone: +1-901-4482947 Fax: +1-901-4487041
Received: February 25, 2014
Revised: October 16, 2014
Accepted: October 28, 2014
Published online: November 26, 2014
Revised: October 16, 2014
Accepted: October 28, 2014
Published online: November 26, 2014
Core Tip
Core tip: In meta-analysis of bivariate P value, keeping the inherent paired structure and thus reserving the correlation between the each member of the paired P-values is critical. In this work, we propose a novel meta-analysis technique which does keep this paired structure intact and thus results in much more favorable sensitivity and specificity characteristics compared to the existing method by George and Mudholkar’ (1983), which treats the P value as independent.