Successful treatment of pyogenic ventriculitis caused by extensively drug-resistant Acinetobacter baumannii with multi-route tigecycline: A case report

Table 1 Antimicrobial susceptibility testing for Acinetobacter baumannii in cerebrospinal fluid

Antibiotic	Susceptibility	MIC (mg/L)
Amikacin	R	> 32
Ceftriaxone	I	> 32
Cefotaxime	R	> 32
Ceftazidime	R	> 16
Cefepime	R	> 16
Tetracycline	R	> 8
Levofloxacin	R	> 4
Selectrin	R	> 2
Piperacillin	R	> 64
Tigecycline	S
Gentamicin	R	> 8
Ciprofloxacin	R	> 2
Tobramycin	R	> 8
Meropenem	R	> 8
Ticarcillin	R	> 64

R: Resistance; I: Intermediary; S: Sensitivity; MIC: Minimum inhibitory concentration.

Table 2 Clinical course and cerebrospinal fluid examination

Hospital stay	Highest body temperature (°C)	Blood WBC (× 109/L)	Blood CRP (mg/L)	CSF glucose (mmol/L)	CSF protein (g/L)	CSF WBC (× 106/L)	Culture of CSF
Day 18	39.1	10.37	104	0.8	4.49	8800	N
Day 24	38.5	9.85	71	0.8	5.75	14000	MDRAB
Day 27	37.6	6.79	65	1.8	2.58	1200	MDRAB
Day 31	37.9	7.02	43	2.9	2.57	590	MDRAB
Day 32	37.2	7.71		2.6	2.25	160	MDRAB
Day 33	37.1	8.08		3.2	2.22	240	MDRAB
Day 36	37.4	8.32	14	3.4	3.88	40	N
Day 41	37.0	8.21		3.5	2.64	68	N
Day 42	37.2	6.51		3	2.13	90	N
Day 43	37.1	5.76	6	3.6	2.32	64	N

MDRAB: Multi-drug resistant Acinetobacter baumannii; N: Negative; CSF: Cerebrospinal fluid; WBC: White blood cell; CRP: C reactive protein.