Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2021; 9(3): 651-658
Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.651
Successful treatment of pyogenic ventriculitis caused by extensively drug-resistant Acinetobacter baumannii with multi-route tigecycline: A case report
Wei Li, Dan-Dong Li, Bo Yin, Dong-Dong Lin, Han-Song Sheng, Nu Zhang
Wei Li, Dan-Dong Li, Bo Yin, Dong-Dong Lin, Han-Song Sheng, Nu Zhang, Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Li DD was in charge of case reviewing and preparation of the manuscript; Li W collected clinic opinions regarding this case and drafted the manuscript; Yin B and Sheng HS participated in the coordination; Zhang N and Lin DD revised the manuscript; all authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Dong Li, PhD, Doctor, Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West Xueyuan Road, Wenzhou 325000, Zhejiang Province, China. andonglmn@163.com
Received: September 2, 2020
Peer-review started: September 2, 2020
First decision: November 8, 2020
Revised: November 19, 2020
Accepted: November 29, 2020
Article in press: January 26, 2021
Published online: January 26, 2021
Core Tip

Core Tip: Pyogenic Ventriculitis caused by extensively drug-resistant (XDR) Acinetobacter baumannii (A. baumannii) is one of the most severe complications associated with craniotomy. We present herein a rare case of pyogenic ventriculitis caused by XDR A. baumannii. Successful treatment was accomplished through multi-route administration of tigecycline, including intravenous combined with continuous ventricular irrigation plus intraventricular administration. This case suggests that multi-route administration of tigecycline can be a therapeutic option against pyogenic ventriculitis caused by XDR A. baumannii.