Copyright
©The Author(s) 2021.
World J Clin Cases. Jul 26, 2021; 9(21): 5860-5872
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.5860
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.5860
Demographic or characteristic | All subjects (n = 3139) | Training set (n = 2902) | Validation set (n = 1047) | P value |
Sex | 0.0239a | |||
Male | 1560 | 1070 | 490 | |
Female | 1579 | 1022 | 557 | |
Age at diagnosis, yr | 0.7318 | |||
20-55 | 853 | 570 | 283 | |
55-65 | 722 | 469 | 253 | |
65-75 | 736 | 497 | 239 | |
> 75 | 828 | 556 | 272 | |
Race | 0.7521 | |||
Black | 378 | 254 | 124 | |
White | 2445 | 1622 | 823 | |
Other (American Indian/Alaska Native, Asian/Pacific Islander) | 316 | 216 | 100 | |
T stage | 0.0141a | |||
Tis | 36 | 27 | 9 | |
T1 | 458 | 306 | 152 | |
T2 | 499 | 329 | 170 | |
T3 | 1522 | 1101 | 421 | |
T4 | 624 | 419 | 205 | |
N stage | 0.3186 | |||
N0 | 1633 | 1084 | 549 | |
N1 | 876 | 573 | 303 | |
N2 | 630 | 435 | 195 | |
M stage | 0.7900 | |||
M0 | 2713 | 1811 | 902 | |
M1 | 426 | 281 | 145 | |
Serum CEA level | 0.7262 | |||
Normal | 1838 | 1230 | 608 | |
Elevated | 1301 | 862 | 439 | |
Tumor deposit | 0.9484 | |||
Negative | 2698 | 1797 | 901 | |
Positive | 441 | 295 | 146 | |
Grade | 0.6182 | |||
I | 279 | 185 | 94 | |
II | 2096 | 1405 | 691 | |
III | 573 | 383 | 190 | |
IV | 191 | 119 | 72 | |
Tumor size | 0.0809 | |||
≤ 30 mm | 876 | 597 | 279 | |
30-50 mm | 934 | 642 | 292 | |
50-65 mm | 555 | 351 | 204 | |
> 65 mm | 774 | 502 | 272 | |
LNR, mean (range) | 0.1173 (0-1) | 0.1197 (0-1) | 0.1124 (0-1) | 0.3699 |
LODDS, mean (range) | -1.6777 (-3.2555-2.9827) | -1.6683 (-3.2555-2.9827) | -1.6964 (-3.2555-2.8457) | 0.5083 |
PLN, mean (range) | 2.2698 (0-48) | 2.3384 (0-48) | 2.1328 (0-48) | 0.2387 |
RLN, mean (range) | 20.7330 (1-90) | 20.6415 (1-90) | 20.9160 (1-90) | 0.4843 |
Variable | Univariate analysis | Multivariate analysis | ||
HR (95%CI) | P value | HR (95%CI) | P value | |
Sex | ||||
Female | Reference | Reference | ||
Male | 0.82 (0.70-0.95) | 0.008b | 1.01 (0.85-1.16) | 0.9277 |
Age at diagnosis, yr | ||||
20-55 | Reference | Reference | ||
55-65 | 1.12 (0.88-1.43) | 0.339 | 1.38 (1.1380-1.6278) | 0.0095b |
65-75 | 1.17 (0.93-1.49) | 0.185 | 1.47 | 0.0017b |
> 75 | 2.69 (2.20-3.30) | < 0.001c | 3.95 (3.7336-4.1610) | < 0.001c |
Race | ||||
Black | Reference | Reference | ||
White | 0.97 (0.78-1.21) | 0.799 | 0.72 (0.4852-0.9513) | 0.0054b |
Other (American Indian/Alaska Native, Asian/Pacific Islander) | 0.68 (0.48-0.95) | 0.023a | 0.64 (0.2921-0.9791) | 0.0097b |
T stage | ||||
Tis | 1.40 (0.50-3.93) | 0.524 | 1.50 (0.4674-2.5395) | 0.4405 |
T1 | Reference | Reference | ||
T2 | 1.75 (1.16-2.63) | 0.00b | 1.21 (0.7887-1.6327) | 0.3745 |
T3 | 3.24 (2.30-4.57) | < 0.001c | 1.56 (1.1640-1.9478) | 0.0271a |
T4 | 8.30 (5.85-11.76) | < 0.001c | 2.58 (2.1710-3.0036) | < 0.001c |
N stage | ||||
N0 | Reference | Reference | ||
N1 | 1.85 (1.53-2.24) | < 0.001c | 1.16 (0.9433-1.3720) | 0.1806 |
N2 | 4.49 (3.76-5.36) | < 0.001c | 1.10 (0.7504-1.4569) | 0.5841 |
M stage | ||||
M0 | Reference | Reference | ||
M1 | 5.95 (5.06-6.99) | < 0.001c | 3.27 (3.0738-3.4599) | < 0.001c |
Serum CEA level | ||||
Elevated | Reference | Reference | ||
Normal | 0.43 (0.37-050) | < 0.001c | 0.78 (0.6157-0.9438) | 0.0030b |
Tumor deposit | ||||
Negative | Reference | Reference | ||
Positive | 3.57 (3.02-4.23) | < 0.001c | 1.44 (1.2366-1.6385) | 0.0004c |
Grade | ||||
I | 0.76 (0.55-1.05) | 0.096 | 0.81 (0.4859-1.1416) | 0.2179 |
II | Reference | Reference | ||
III | 2.42 (2.04-2.86) | < 0.001c | 1.14 (0.9361-1.3457) | 0.2071 |
IV | 2.38 (1.82-3.10) | < 0.001c | 1.15 (0.8608-1.4452) | 0.3396 |
Tumor size | ||||
≤ 30 mm | Reference | Reference | ||
30-50 mm | 1.98 (1.59-2.46) | < 0.001c | 1.00 (0.7592-1.2460) | 0.9832 |
50-65 mm | 2.10 (1.64-2.69) | < 0.001c | 1.11 (0.8352-1.3831) | 0.4585 |
> 65 mm | 2.67 (2.14-3.34) | < 0.001c | 1.11 (0.8608-1.4452) | 0.4209 |
LODDS | ||||
≤ -0.6504 | Reference | Reference | ||
> -0.6504 | 4 (3.44-4.65) | < 0.001c | 2.20 (1.9068-2.5030) | < 0.001c |
LNR | ||||
≤ 0.1795 | Reference | - | - | |
> 0.1795 | 3.97 (3.41-4.62) | < 0.001c | - | - |
C-index | AIC | AUC | |||
1-yr | 3-yr | 5-yr | |||
N stage | 0.6712 | 9906.03 | 0.695 | 0.702 | 0.696 |
LODDS | 0.6497 | 9887.95 | 0.690 | 0.673 | 0.660 |
LNR | 0.6494 | 9890.20 | 0.689 | 0.673 | 0.659 |
- Citation: Li BW, Ma XY, Lai S, Sun X, Sun MJ, Chang B. Development and validation of a prognostic nomogram for colorectal cancer after surgery. World J Clin Cases 2021; 9(21): 5860-5872
- URL: https://www.wjgnet.com/2307-8960/full/v9/i21/5860.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i21.5860