Crizotinib-induced acute fatal liver failure in an Asian ALK-positive lung adenocarcinoma patient with liver metastasis: A case report

Table 1 Case reports of crizotinib-induced fulminant hepatitis, 2013-2017

Author	Therapy line	Initial dose	Liver injury	Occurrence time	Outcome
Ripault et al[18], 2013	Not mentioned	500 mg Qd	Acute hepatitis	Day 60	Transaminases returned to normal
Sato et al[19], 2014	First-line	400 mg Qd	Fulminant hepatitis	Day 29	Died of liver failure
Van Geel et al[20], 2016	Second-line	250 mg Bid	Fulminant liver failure	Day 24	Died of liver failure
Yasuda et al[21], 2017	Second-line	250 mg Bid	Hepatitis	Day 16	Died of respiratory failure
Present case	First-line	250 mg Bid	Fulminant liver failure	Day 46	Died of liver failure

Qd: Every day; Bid: Twice a day.