Neuroendoscopic and microscopic transsphenoidal approach for resection of nonfunctional pituitary adenomas

Table 1 Clinical data of the two groups

	Neuroendoscopy group, 138 cases	Microscopy group, 113 cases	P-value
Gender, male/female	65/73	54/59	0.914
Age in yr	44.5 ± 1.5	42.9 ± 1.3	0.413
Course of disease in mo	25.9 ± 4.2	26.7 ± 3.5	0.887
Clinical manifestations, n (%)
Headache	57 (41.3%)	47 (41.6%)	0.963
Visual impairment	67 (48.6%)	60 (53.1%)	0.474
Sexual dysfunction	4 (2.9%)	3 (2.7%)	1.000
Menstrual disorder	20 (14.5%)	26 (23.0%)	0.083
Tumor diameter in mm	27.7 ± 6.2	26.3 ± 7.8	0.782
Tumor location, n (%)
Confined to intrasellar region	43 (31.2%)	42 (37.2%)	0.317
Grow into suprasellar region	55 (39.9%)	38 (33.6%)	0.310
Invades cavernous sinus	21 (15.2%)	11 (9.7%)	0.195
Invades sphenoid sinus	10 (7.2%)	12 (10.6%)	0.347
Invades cavernous and sphenoid sinuses	9 (6.5%)	10 (8.9%)	0.488

Table 2 Treatment outcomes in the two groups

	Neuroendoscopy group, 138 cases	Microscopy group, 113 cases	P-value
Cure, n (%)	114 (82.6%)	97 (85.8%)	0.486
Improvement, n (%)	125 (90.6%)	106 (93.8%)	0.348
Relapse, n (%)	7 (5.1%)	11 (9.7%)	0.154
Duration of postoperative hospital stay in d	8.4 ± 0.6	11.2 ± 0.6	0.001
Duration of operation in min	167.2 ± 9.6	199.7 ± 9.3	0.016
Intraoperative blood loss in mL	83.4 ± 9.3	138.8 ± 13.6	0.001

Table 3 Postoperative complications in the two groups

	Neuroendoscopy group, 138 cases	Microscopy group, 113 cases	P-value
Diabetes insipidus	6 (4.3%)	37 (32.7%)	0.000
Cerebrospinal fluid leakage	10 (7.2%)	12 (10.6%)	0.347
Electrolyte disturbance	11 (8.0%)	23 (20.4%)	0.004
Hypopituitarism	32 (23.2%)	35 (30.9%)	0.165
Intracranial infection	9 (6.5%)	11 (9.7%)	0.350