Diagnostic performance of 99mTc-PSMA SPECT/CT in primary prostate carcinoma

Table 1 Data of subjects included in the study with visual analysis of ^99mTc-PSMA SPECT-CT

Sl.No	Age (years)	S.PSA (ng/mL)	PSMA uptake			HPE for malignancy (GS)
			Primary	Lymph nodes	Distant
1	76	80.46	No uptake	-	-	Positive (GS-4+5)
2	73	7.19	No uptake	-	-	Negative
3	66	4.2	No uptake	-	-	Negative
4	75	48.8	Mild diffuse	-	-	Negative
5	50	7.7	Mild diffuse	-	-	Negative
6	72	8.1	No uptake	-	-	Negative
7	70	100	Increased	-	Bones	Positive (GS-5+5)
8	80	10.4	No uptake	-	-	Negative
9	62	10.2	No uptake	-	-	Positive (GS-3+3)
10	82	> 100	Increased	Left pelvic	-	Positive (GS-5+5)
11	55	> 100	Increased	Pelvic	Lungs, bones	Positive (GS-5+5)
12	54	> 100	Increased	Abdomino-pelvic	Bones	Positive (GS-5+3)
13	73	> 100	Increased	Abdomino-pelvic, left sclv.	Bones	Positive (GS-4+5)
14	59	> 100	Increased	Abdomino-pelvic nodes	-	Positive (GS-5+5)
15	65	932	Increased	Abdomino-pelvic, mediastinal	Lung, bones	Positive (GS-5+5)
16	64	> 100	Increased	-	Bones	Positive (GS-3+3)
17	66	55.5	Increased	Pelvic	-	Positive (GS-3+3)
18	66	> 150	Increased	Pelvic-mediastinal	Bones	Positive (GS-5+4)
19	69	24.8	Increased	Abdomino-pelvic, left sclv.	-	Positive (GS-4+5)
20	59	86.5	Increased	Abdo-pelvic nodes	-	Positive (GS-3+4)
21	64	> 100	Increased	Mediastinal-abdomino-pelvic, left sclv.	Bones	Positive (GS-5+5)
22	66	51	No uptake	-	-	Negative
23	59	44.9	Increased	-	-	Positive (GS-3+4)
24	70	> 100	Increased	Abdomino-pelvic	Bones	Positive (GS-5+5)
25	77	25.7	No uptake	-	-	Negative
26	80	8.5	Mild diffuse	-	-	Negative
27	54	17.5	No uptake	-	-	Negative
28	62	100	Increased	Retroperitoneal, abdomino-pelvic, inguinal, and sclv.	Bones	Positive (GS-5+3)
29	58	55.8	No uptake	-	Bones	Positive (GS-3+4)

Sl.No: Serial number; Sclv.: Supraclavicular; HPE: Histopathological examination; GS: Gleason’s score.

Table 2 Mean values of semi-quantitative parameters (count ratios) in benign and malignant groups

Parameter	mean ± SD in benign group (n = 9)	mean ± SD in malignant group (n = 20)	P value
Prostate:background count ratio	6.65 ± 5.17	37.18 ± 48.85	0.004
Prostate:liver count ratio	1.14 ± 0.56	5.35 ± 7.35	0.023

P value < 0.05 is statistically significant.

Table 3 Results of semi-quantitative parameters in differentiating malignant from benign pathologies

Parameter	AUC	95%CI	P value	Cut-off (ROC)	Sensitivity	Specificity
Prostate:background ratio	0.833	0.677-0.990	0.005	10.45	85%	88.9%
Prostate:liver ratio	0.767	0.596-0.937	0.024	1.15	75%	77.8%

P value < 0.05 is statistically significant; AUC: Area under the curve; ROC: Receiver operating characteristic curve analysis.