Tuberous sclerosis complex combined with primary lymphedema: A case report

Table 1 Summary of cases of tuberous sclerosis complex with primary lymphedema from 1986 to 2023

No	Ref.	Year	Number	Gender	Age (yr)	Edemasite	Gene	Treatment
1	Cottafava et al[16]	1986	1	Female	7	Left lower limb	Unknown	Anti convulsive drugs + anti ACTH drugs
2	Hirsch et al[17]	1999	1	Female	28	Left lower limb	Unknown	Subcutaneous lymphangiectomy + diuretic + elastic socks
3	Voudris et al[18]	2003	1	Female	5	Left lower limb	Unknown	Unknown
4	Lucas and Andrade[19]	2011	1	Female	1	Right lower limb	TSC1	Unknown
5	Sukulal and Namboodiri[12]	2012	1	Female	0	Left lower limb	Unknown	Unknown
6	Navarre and Poitras[13]	2014	1	Male	5	Left lower limb	TSC2	Fasectomy + toe amputation + antibiotics + enoxaparin + warfarin
7	Prato et al[20]	2014	1	Female	4	Left upper limb	TSC2	Carbamazepine + topiramate + everolimus + amoxicillin-clavulanate potassium
8	Geffrey et al[9]	2014	2	Female/Female	8/15	Left lower limb/Left lower limb	TSC2/TSC2	Rapamycin + lymphedema therapy
9	Hoshiai et al[21]	2015	2	Female/Female	2/0	Right lower limb/Right upper limb	Unknown	Unknown
10	Saffari et al[22]	2019	1	Male	6	lower limb but unknown left and right	TSC2	Everolimus
11	Wiemer-Kruel et al[14]	2020	1	Male	7	Left lower limb	TSC2	Levetiracetam + repair of aortic aneurysm + everolimus
12	Kaneshi et al[15]	2020	1	Male	0	lower limb but unknown left and right	Unknown	Ileostomy decompression + antibiotics + lymphedema therapy
13	Lin et al[11]	2020	1	Male	3	Left lower limb	TSC1	Albumin + diuretics
14	Klinner et al[23]	2020	1	Female	0	Right lower limb	TSC1	Aminohexenoic acid + lymphatic drainage + bandage compression
15	This case	2023	1	Male	16	Right lower limb	TSC2	Sirolimus + oxcarbazepine + liposuction

TSC: Tuberous sclerosis complex.