Diagnosis and treatment discussion of congenital factor VII deficiency in pregnancy: A case report

Figure 1 Fluctuation of factor VII activity and corresponding prothrombin time value in the pregnant woman. Medication: Intravenous injection of recombinant factor VIIa (NovoSeven^®, Novo Nordisk A/S, Bagsvaerd, Denmark) 5 mg, (90 μg/kg). PT: Prothrombin time.

Figure 2 Diagnosis flow chart of pregnancy with congenital factor VII deficiency. vWD: Von Willebrand disease; APS: Antiphospholipid antibody syndrome; PLT: Platelet; APTT: Activated partial thromboplastin time; PT: Prothrombin time; TT: Plasma thrombin time; FIB: Fibrinogen; VKA: Vitamin K antagonist; ITP: Idiopathic thrombocytopenic purpura; CTD: Diffuse connective tissue disease; TTP: Thrombocytopenic purpura; HELLP: HELLP syndrome; AFLP: Acute fatty liver in pregnancy; DIC: Diffuse intravascular coagulation; FVII: Factor VII; FVIID: Factor VII deficiency.

Figure 3 Selection of delivery mode and corresponding recombinant factor VIIa medication scheme of congenital factor VII deficiency pregnant women during delivery. FVIID: Factor VII deficiency; FVII: Factor VII; rFVIIa: Recombinant factor VIIa.