Vasculitis with renal involvement in essential mixed cryoglobulinemia: Case report and mini-review

Figure 1 Detection of essential mixed cryoglobulinemic syndrome in a female patient. A: Precipitated cryoproteins from the cryoglobulin detection test are shown at the bottom of the tube, with a cryocrit measurement of approximately 6%; B: Immunotyping of cryoglobulins at 37 °C revealed a mixture of polyclonal immunoglobulin (Ig) G and monoclonal IgMκ (black arrows); C: Hematoxylin and eosin-stained renal biopsy showing diffuse moderate mesangial proliferation, numerous wireloop lesions and hyaline thrombi in capillary lumina (black arrows) (magnification × 200); D: Periodic acid-Schiff staining from the same biopsy showing extensive hyaline thrombi in the capillary lumina (arrow) (magnification × 200).