Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

Figure 1 Ultrasound features. A: The tumor was solid with heterogeneous echo in case 4; B and C: Color Doppler flow imaging displayed rich intralesional vascularization in the solid part of the lesion.

Figure 2 Computed tomography features. A: A soft tissue mass with heterogeneous density occupied the pelvic cavity in case 1; B: Computed tomography (CT) scan revealed a multiseptated mixed solid and cystic mass in case 12; C: Enhanced CT showed marginal enhancement of the tumor in case 5; D: Heterogenous enhancement of the solid part.

Figure 3 Histological and immunohistochemical large cell neuroendocrine carcinoma. A: Tumor cells are arranged in nests, with relatively abundant basophilic cytoplasm, large round-to-oval nuclei and frequent mitosis in case 10; B: Small cell carcinoma of the ovary: Tumor cells are arranged in an organoid pattern, and some of the cells are spindle-shaped. The nucleus is oat-like, with abundant mitotic and apoptotic activity in case 4; C-E: Neuroendocrine carcinoma positive for CD56 (C), chromogranin A (D) and synaptophysin (E); F: Positive for cytokeratin.