Coxsackievirus A6 was the most common enterovirus serotype causing hand, foot, and mouth disease in Shiyan City, central China

Figure 1 Yearly distribution of hand, foot, and mouth disease cases from 2016 to 2020, in Shiyan, central China. A: Yearly distribution of hand, foot, and mouth disease (HFMD) cases, severe cases, and fatal cases; B: Yearly incidence rates of HFMD; C: Yearly distribution of laboratory-confirmed HFMD cases and enterovirus A71 vaccine inoculation numbers. CV-A16: Coxsackievirus A16; EV-A71: Enterovirus A71.

Figure 2 Enterovirus serotypes of 196 hospitalized hand, foot, and mouth disease patients enrolled in this study from 2018 to 2020 in Shiyan, central China. A: Enterovirus A71 specific, coxsackievirus A16 specific, and pan-enterovirus real-time reverse transcription-polymerase chain reaction Kits were used to identify enterovirus-positive specimens; B: The 5'-untranslated region sequences identified enterovirus serotypes of 168 enterovirus-positive samples. EU-positive: Enterovirus-positive; CV: Coxsackievirus.

Figure 3 Clinical characteristics of hand, foot, and mouth disease in Shiyan from 2018 to 2020. A: The constituent ratio of different enterovirus serotypes associated with hand, foot, and mouth disease cases in different age groups; B: Numbers of enterovirus-positive cases with or without fever; C: The constituent ratio of enterovirus-positive cases with or without myocardial damage. ^aP < 0.05. EU-positive: Enterovirus-positive; CV: Coxsackievirus.