Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2021; 9(32): 9997-10005
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9997
Gastrointestinal symptoms as the first sign of chronic granulomatous disease in a neonate: A case report
Er-Yan Meng, Zi-Ming Wang, Bing Lei, Li-Hong Shang
Er-Yan Meng, Bing Lei, Li-Hong Shang, Division of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zi-Ming Wang, Chongqing Medical College, Chongqing 400016, China
Author contributions: Meng EY and Shang LH conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. Wang ZM and Lei B collected data, carried out the initial analyses, and reviewed the manuscript; all authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Informed consent statement: Informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Hong Shang, MD, Doctor, Division of Neonatology, The Third Affiliated Hospital of Zhengzhou University, No. 7 Kangfuqian Street, Zhengzhou 450052, Henan Province, China. shanglihong10@163.com
Received: June 30, 2021
Peer-review started: June 30, 2021
First decision: July 26, 2021
Revised: July 27, 2021
Accepted: September 23, 2021
Article in press: September 30, 2021
Published online: November 16, 2021
Core Tip

Core Tip: Most chronic granulomatous diseases (CGDs) present with life-threatening recurrent bacterial and fungal infections, usually diagnosed in childhood. We describe a newborn with CGD that initially showed gastrointestinal symptoms. CGD cases with gastrointestinal manifestations as the first sign are very rare. To the best of our knowledge, this might be the youngest case of confirmed CGD with gastrointestinal involvement.