Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2021; 9(32): 9847-9856
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9847
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9847
Management of pouch related symptoms in patients who underwent ileal pouch anal anastomosis surgery for adenomatous polyposis
Ophir Gilad, Guy Rosner, Revital Kariv, Nathan Gluck, Hana Strul, Department of Gastro
Eli Brazowski, Department of Pathology, Tel-Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel
Author contributions: Gilad O, Gluck N and Strul H participated in study design, data acquisition, analysis and interpretation; Gluck N and Strul H contributed equally as senior co-authors; Brazowski E reviewed pathology specimens and participated in data analysis and critical revision of article; Kariv R and Rosner G participated in data analysis and critical revision of manuscript.
Institutional review board statement: This study is registered at Tel-Aviv Medical Center Trial Registry, and was approved by the Tel-Aviv Medical Center Helsinki Committee. The registration identification number is 0518-14-TLV.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of conflict of interest.
Data sharing statement: None.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ophir Gilad, MD, Doctor, Department of Gastroenterology and Hepatology, Tel-Aviv Sourasky Medical Center, Weizman 6, Tel Aviv 6423906, Israel. ophir.gilad@gmail.com
Received: June 12, 2021
Peer-review started: June 12, 2021
First decision: June 30, 2021
Revised: July 23, 2021
Accepted: September 23, 2021
Article in press: September 23, 2021
Published online: November 16, 2021
Peer-review started: June 12, 2021
First decision: June 30, 2021
Revised: July 23, 2021
Accepted: September 23, 2021
Article in press: September 23, 2021
Published online: November 16, 2021
Core Tip
Core Tip: We present our results of a cohort of 33 adenomatous polyposis syndromes patients who underwent ileal pouch anal anastomosis surgery and developed pouch related symptoms during their follow up. We evaluated their response to treatment modalities taken from the world of ulcerative colitis patients, and irritable bowel disease patients. Antibiotics and anti-inflammatory modalities had minimal effect on outcome. Dietary modifications and probiotics seem to confer the greatest benefit for pouch-related symptoms. No therapy had a significant impact on endoscopic or histologic findings.