Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2021; 9(3): 540-551
Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.540
Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.540
Circulating immune parameters-based nomogram for predicting malignancy in laryngeal neoplasm
Min Chen, Yi Fang, Yue Yang, Pei-Jie He, Lei Cheng, Hai-Tao Wu, Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai 200031, China
Author contributions: Chen M performed the study, analyzed data and wrote the original manuscript; Fang Y collected data and corrected the manuscript; Yang Y participated in data analysis and study design; He PJ and Cheng L reviewed and edited the manuscript; Wu HT designed the study and corrected the manuscript.
Supported by Health and Family Planning Commission of Shanghai Municipality of China , No. 2019SY059 .
Institutional review board statement: The study was reviewed and approved by the Eye, Ear, Nose, and Throat Hospital of Fudan University Institutional Review Board (Approval No. 2017042-1).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: No potential conflict of interest was reported by the authors.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Tao Wu, PhD, Chief Physician, Doctor, Surgeon, Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China. eentwuhaitao@163.com
Received: August 6, 2020
Peer-review started: August 6, 2020
First decision: November 14, 2020
Revised: November 28, 2020
Accepted: December 10, 2020
Article in press: December 10, 2020
Published online: January 26, 2021
Peer-review started: August 6, 2020
First decision: November 14, 2020
Revised: November 28, 2020
Accepted: December 10, 2020
Article in press: December 10, 2020
Published online: January 26, 2021
Core Tip
Core Tip: Malignancy prediction remains important to preoperative diagnosis and postoperative follow-up in laryngeal neoplasm. There are continuing problems in differentiating premalignant lesions from malignant lesions of the larynx before surgery. Our finding suggested that laryngeal malignant lesions and premalignant lesions exhibit changes in the circulating immune phenotype. This circulating immune parameters-based novel nomogram could be appropriately applied in preoperative individualized prediction of malignancy in patients with laryngeal neoplasm.