Yan J, He YS, Song Y, Chen XY, Liu HB, Rao CY. False positive anti-hepatitis A virus immunoglobulin M in autoimmune hepatitis/primary biliary cholangitis overlap syndrome: A case report. World J Clin Cases 2021; 9(22): 6464-6468 [PMID: 34435013 DOI: 10.12998/wjcc.v9.i22.6464]
Corresponding Author of This Article
Chun-Yan Rao, MS, Doctor, Department of Hepatology, Chongqing Hospital of Traditional Chinese Medicine, No. 6 Seventh Branch Road in Panxi, Jiangbei District, Chongqing 400021, China. chunyanrao@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2021; 9(22): 6464-6468 Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6464
False positive anti-hepatitis A virus immunoglobulin M in autoimmune hepatitis/primary biliary cholangitis overlap syndrome: A case report
Jun Yan, Yan-Sha He, Yi Song, Xin-Yu Chen, Hua-Bao Liu, Chun-Yan Rao
Jun Yan, Yan-Sha He, Yi Song, Xin-Yu Chen, Hua-Bao Liu, Chun-Yan Rao, Department of Hepatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China
Author contributions: Yan J, Rao CY contributed to concept and design of the manuscript; Rao CY, He YS and Song Y reviewed the literature and drafted the manuscript; Chen XY and Liu HB were responsible for the revision of the manuscript; all authors issued the final approval for the version to be submitted.
Supported byNatural Science Foundation of Chongqing, China, No. cstc2020jcyj-msxmX0630; and Traditional Chinese Medicine United Foundation of Health Commission and Science & Technology Bureau of Chongqing, China, No. 2019ZY3202.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Yan Rao, MS, Doctor, Department of Hepatology, Chongqing Hospital of Traditional Chinese Medicine, No. 6 Seventh Branch Road in Panxi, Jiangbei District, Chongqing 400021, China. chunyanrao@126.com
Received: April 10, 2021 Peer-review started: April 10, 2021 First decision: April 23, 2021 Revised: April 30, 2021 Accepted: May 24, 2021 Article in press: May 24, 2021 Published online: August 6, 2021
Core Tip
Core Tip: Autoimmune hepatitis (AIH)/primary biliary cholangitis (PBC) overlap syndrome is the specific clinical manifestation of AIH, which is an immune-mediated liver disease. Environmental factors including viral infections have been documented to externally trigger AIH. The association between hepatitis A virus (HAV) and AIH has been described for many years. But relying solely on anti- HAV immunoglobulin M (IgM) to diagnose acute HAV infection is not adequate. This case highlights that false-positive anti-HAV IgM might be caused by the cross-reaction of antibodies in individuals with autoimmune diseases or chronic or acute infections. HAV nucleic acid amplification can be used more broadly during the diagnosis workup to confirm HAV infection, especially in patients testing positive for anti-HAV IgM with a low cutoff value.
