Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2020; 8(8): 1350-1360
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1350
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1350
Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma
Xin Wu, Bing-Lu Li, Chao-Ji Zheng, Xiao-Dong He, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: All authors helped to write the paper; Wu X wrote the manuscript and analyzed the data; Li BL contributed to the conception and design of the paper and analyzed the data; Zheng CJ and He XD contributed to the writing of the manuscript and the conception and design of the paper.
Supported by Fundamental Research Funds for the Central Universities of China , No. 3332019022 .
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bing-Lu Li, MD, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, China. pumchlibinglu@163.com
Received: January 11, 2020
Peer-review started: January 11, 2020
First decision: February 26, 2020
Revised: March 4, 2020
Accepted: April 4, 2020
Article in press: April 4, 2020
Published online: April 26, 2020
Peer-review started: January 11, 2020
First decision: February 26, 2020
Revised: March 4, 2020
Accepted: April 4, 2020
Article in press: April 4, 2020
Published online: April 26, 2020
Core Tip
Core tip: Surgery is the primary treatment for papillary thyroid microcarcinoma. Prophylactic central lymph node dissection is controversial due to its potential oncologic benefit and side effects. This review provides an overview of previous studies on the predictive factors for lymph node metastases in patients with papillary thyroid microcarcinoma. The most commonly reported factors include age, gender, tumor size and location, multifocality, bilaterality, extrathyroidal extension, and abnormal lymph node found using ultrasound. Prophylactic central neck dissection should be selectively performed only in high-risk patients.