Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2020; 8(2): 264-275
Published online Jan 26, 2020. doi: 10.12998/wjcc.v8.i2.264
Published online Jan 26, 2020. doi: 10.12998/wjcc.v8.i2.264
Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit
Zhi Zheng, Rui Xu, Jie Yin, Jun Cai, Guang-Yong Chen, Jun Zhang, Zhong-Tao Zhang, Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Zheng Z and Xu R contributed equally to this work; Zheng Z and Xu R carried out the studies, participated in collecting the data, and drafted the manuscript; Yin J and Cai J performed the statistical analysis and participated in its design; Zhang J, Chen GY, and Zhang ZT helped to draft the manuscript; all authors read and approved the final manuscript.
Supported by the Beijing Health System of High Level Health Technical Personal Training Project , No. 2013-3-067 ; and Beijing Municipal Science and Technology Commission , No. D171100006517003 .
Institutional review board statement: This study was approved by the Ethics Committee of Beijing Friendship Hospital, Capital Medical University.
Informed consent statement: All participants provided written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jun Zhang, MD, Professor, Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing 100050, China. zhangjun5986@ccmu.edu.cn
Received: November 11, 2019
Peer-review started: November 11, 2019
First decision: November 22, 2019
Revised: December 15, 2019
Accepted: January 1, 2020
Article in press: January 1, 2020
Published online: January 26, 2020
Peer-review started: November 11, 2019
First decision: November 22, 2019
Revised: December 15, 2019
Accepted: January 1, 2020
Article in press: January 1, 2020
Published online: January 26, 2020
Core Tip
Core tip: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disease easily causing secondary malignant changes without effective treatments. Pathological examination and gene detection are the gold standards for detecting malignant PJS polyps. Patients with PJS have higher malignant tumor susceptibility. Hence, we need to surveil regularly and take positive measures for removing Peutz-Jeghers polyps.